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Figure 3 | BMC Medicine

Figure 3

From: Human cellular restriction factors that target HIV-1 replication

Figure 3

The effect of host cell cyclophilin A on HIV-1 transduction. Host cell cyclophilin A (shown in green) binds to the HIV-1 CA and regulates CA-recognition by host cell restriction factors. In some cases, cyclophilin A promotes HIV-1 CA recognition by these factors (for example, by rhesus macaque TRIM5alpha). In other cases, human cells for example, cyclophilin A seems to prevent recognition by these factors. The effect of cyclophilin A is, therefore, determined by the effect of the restriction factor, which may act at the time of reverse transcription, nuclear import, or integration.

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