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Table 5 Results of the generalised linear latent and mixed model for TESI, TWOSI and 0.5 standard deviation (SD) increased

From: Suicidal ideation during treatment of depression with escitalopram and nortriptyline in Genome-Based Therapeutic Drugs for Depression (GENDEP): a clinical trial

  TESI TWOSI 0.5 SD
  OR Pvalue 95% CI OR Pvalue 95% CI OR Pvalue 95% CI
Age (continuous) 2.04 0.079 0.92 to 4.5 0.91 0.425 0.71 to 1.16 1.33 0.317 0.76 to 2.34
Age (categorical) 6.57 0.149 0.51 to 36.75 0.83 0.629 0.39 to 1.77 1.14 0.452 0.81 to 1.59
Gender 1.76 0.178 0.77 to 3.98 2.33 0.188 0.66 to 8.24 1.91 0.287 0.58 to 6.33
Randomisation status 1.16 0.667 0.58 to 2.32 4.39 0.022 1.23 to 15.64 6.05 0.003 1.82 to 20.07
Drug (nortriptyline vs escitalopram) 1.57 0.431 0.51 to 4.85 1.05 0.797 0.71 to 1.59 1.01 0.947 0.73 to 1.39
Observed mood dimension 2.92 <0.0001 1.92 to 4.46 3.28 <0.0001 2.49 to 4.32 4.16 <0.0001 3.24 to 5.35
Age at onset 0.16 0.01 0.04 to 0.64 0.66 0.296 0.30 to 1.44 0.42 0.037 0.18 to 0.95
Number of episodes (more than 3) 9.7 0.031 1.23 to 76.2 4.17 0.172 0.54 to 32.13 11.05 0.022 1.41 to 86.93
Duration 0.95 0.291 0.86 to 1.04 1 0.325 0.99 to 1.01 1.01 0.065 0.99 to 1.02
Switchers 2.2 0.022 1.11 to 4.35 5.94 <0.0001 4.19 to 8.44 9.47 <0.0001 6.57 to 13.6
Increasing dose 2.03 0.92 0.44 to 9.48 1.31 0.269 0.81 to 2.11 1.42 0.184 0.85 to 2.37
Decreasing dose 1.29 0.84 0.18 to 4.29 0.63 0.567 0.13 to 3 1.05 0.95 0.24 to 4.51
History of suicide attempts 0.85 0.898 0.07 to 9.48 2.02 0.015 1.15 to 3.45 3.59 <0.0001 2.31 to 5.58
Marital status          
Married/cohabiting 4.66 0.017 1.32 to 16.42 0.73 0.285 0.41 to 1.29 0.79 0.723 0.23 to 2.81
Separated/divorced 0.24 0.065 0.05 to 1.09 1.24 0.516 0.64 to 2.42 0.81 0.771 0.19 to 3.44
Single 0.38 0.162 0.11 to 1.47 2.02 0.094 0.88 to 4.58 1.85 0.507 0.31 to 11.28
Occupation          
Full-time work 0.27 0.073 0.04 to 1.16 0.79 0.402 0.45 to 1.38 0.31 0.062 0.11 to 1.09
Part-time work 1.71 0.725 0.09 to 18.03 1.14 0.754 0.51 to 2.52 1.51 0.631 0.28 to 8.17
Unemployed 6.84 0.002 2 to 23.3 0.75 0.323 0.41 to 1.33 1.82 0.337 0.53 to 6.29
Retired 0.93 0.96 0.08 to 9.58 3.25 0.009 1.33 to 7.92 9.28 <0.0001 4.61 to 18.72
Student* - - - 1.06 0.929 0.32 to 3.46 0.33 0.398 0.02 to 4.34
Children (yes vs no) 1.04 0.978 0.05 to 21.43 0.57 0.124 0.29 to 1.16 0.49 0.378 0.11 to 2.33
Education 1.12 0.504 0.79 to 1.59 0.95 0.264 0.87 to 1.04 0.91 0.358 0.76 to 1.11
Gender by drug interaction   <0.0001    <0.0001    <0.0001  
Drug among men (nortriptyline vs escitalopram) 9.83 0.01 1.72 to 56.27 2.47 0.004 1.34 to 4.56 3.51 <0.0001 1.92 to 6.39
  1. aNo students with TESI were observed.
  2. CI = confidence interval; OR = odds ratio; TESI = treatment emergent suicidal ideation; TWOSI = treatment worsening suicidal ideation.