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Table 5 Results of the generalised linear latent and mixed model for TESI, TWOSI and 0.5 standard deviation (SD) increased

From: Suicidal ideation during treatment of depression with escitalopram and nortriptyline in Genome-Based Therapeutic Drugs for Depression (GENDEP): a clinical trial

 

TESI

TWOSI

0.5 SD

 

OR

Pvalue

95% CI

OR

Pvalue

95% CI

OR

Pvalue

95% CI

Age (continuous)

2.04

0.079

0.92 to 4.5

0.91

0.425

0.71 to 1.16

1.33

0.317

0.76 to 2.34

Age (categorical)

6.57

0.149

0.51 to 36.75

0.83

0.629

0.39 to 1.77

1.14

0.452

0.81 to 1.59

Gender

1.76

0.178

0.77 to 3.98

2.33

0.188

0.66 to 8.24

1.91

0.287

0.58 to 6.33

Randomisation status

1.16

0.667

0.58 to 2.32

4.39

0.022

1.23 to 15.64

6.05

0.003

1.82 to 20.07

Drug (nortriptyline vs escitalopram)

1.57

0.431

0.51 to 4.85

1.05

0.797

0.71 to 1.59

1.01

0.947

0.73 to 1.39

Observed mood dimension

2.92

<0.0001

1.92 to 4.46

3.28

<0.0001

2.49 to 4.32

4.16

<0.0001

3.24 to 5.35

Age at onset

0.16

0.01

0.04 to 0.64

0.66

0.296

0.30 to 1.44

0.42

0.037

0.18 to 0.95

Number of episodes (more than 3)

9.7

0.031

1.23 to 76.2

4.17

0.172

0.54 to 32.13

11.05

0.022

1.41 to 86.93

Duration

0.95

0.291

0.86 to 1.04

1

0.325

0.99 to 1.01

1.01

0.065

0.99 to 1.02

Switchers

2.2

0.022

1.11 to 4.35

5.94

<0.0001

4.19 to 8.44

9.47

<0.0001

6.57 to 13.6

Increasing dose

2.03

0.92

0.44 to 9.48

1.31

0.269

0.81 to 2.11

1.42

0.184

0.85 to 2.37

Decreasing dose

1.29

0.84

0.18 to 4.29

0.63

0.567

0.13 to 3

1.05

0.95

0.24 to 4.51

History of suicide attempts

0.85

0.898

0.07 to 9.48

2.02

0.015

1.15 to 3.45

3.59

<0.0001

2.31 to 5.58

Marital status

         

Married/cohabiting

4.66

0.017

1.32 to 16.42

0.73

0.285

0.41 to 1.29

0.79

0.723

0.23 to 2.81

Separated/divorced

0.24

0.065

0.05 to 1.09

1.24

0.516

0.64 to 2.42

0.81

0.771

0.19 to 3.44

Single

0.38

0.162

0.11 to 1.47

2.02

0.094

0.88 to 4.58

1.85

0.507

0.31 to 11.28

Occupation

         

Full-time work

0.27

0.073

0.04 to 1.16

0.79

0.402

0.45 to 1.38

0.31

0.062

0.11 to 1.09

Part-time work

1.71

0.725

0.09 to 18.03

1.14

0.754

0.51 to 2.52

1.51

0.631

0.28 to 8.17

Unemployed

6.84

0.002

2 to 23.3

0.75

0.323

0.41 to 1.33

1.82

0.337

0.53 to 6.29

Retired

0.93

0.96

0.08 to 9.58

3.25

0.009

1.33 to 7.92

9.28

<0.0001

4.61 to 18.72

Student*

-

-

-

1.06

0.929

0.32 to 3.46

0.33

0.398

0.02 to 4.34

Children (yes vs no)

1.04

0.978

0.05 to 21.43

0.57

0.124

0.29 to 1.16

0.49

0.378

0.11 to 2.33

Education

1.12

0.504

0.79 to 1.59

0.95

0.264

0.87 to 1.04

0.91

0.358

0.76 to 1.11

Gender by drug interaction

 

<0.0001

  

<0.0001

  

<0.0001

 

Drug among men (nortriptyline vs escitalopram)

9.83

0.01

1.72 to 56.27

2.47

0.004

1.34 to 4.56

3.51

<0.0001

1.92 to 6.39

  1. aNo students with TESI were observed.
  2. CI = confidence interval; OR = odds ratio; TESI = treatment emergent suicidal ideation; TWOSI = treatment worsening suicidal ideation.