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Table 4 Odds ratios for baseline and time-varying predictors of adherence ≥ 90%.

From: Adherence to isoniazid prophylaxis among HIV-infected children: a randomized controlled trial comparing two dosing schedules

Baseline characteristics Univariate model
OR (95% CI) P*
Multivariate model†
AOR (95% CI) P*
Dosing schedule (prophylaxis group) Three times a week 1 1
  Daily 0.88 (0.66, 1.17) 0.38 0.85 (0.64, 1.11) 0.23
Study site RCCH 1 1
  TCH 1.25 (0.95, 1.67) 0.11 1.12 (0.82, 1.54) 0.46
Gender Male 1 1
  Female 1.17 (0.87, 1.57) 0.30 1.11 (0.82, 1.50) 0.51
Number of individuals in house ≤ 5 1 1
  > 5 0.77 (0.57 1.02) 0.07 0.71 (0.54, 0.95) 0.02
Brick house No 1 -
  Yes 0.98 (0.73, 1.30) 0.87  
Tap water in house No 1 -
  Yes 1.07 (0.80, 1.43) 0.64  
Flush toilet in house No 1 -
  Yes 1.08 (0.82, 1.44) 0.57  
Electricity in house No 1 -
  Yes 0.93 (0.61, 1.41) 0.74  
Time-varying characteristics
Age at visit < 1 year 1 1
  1-4 years 0.77 (0.6, 0.98) 0.03 1.47 (0.91, 2.37) 0.11
  > 4 years 1.40 (1.09, 1.80) 0.008 1.96 (1.16, 3.32) 0.012
Time on study at visit < 1 year 1 1
  ≥ 1 year 0.82 (0.67, 1.01) 0.06 0.83 (0.66, 1.05) 0.12
CDC clinical N or A 1 1
   stage at visit B 1.11 (0.85, 1.46) 0.44 0.85 (0.54, 1.34) 0.48
  C 0.86 (0.65, 1.14) 0.30 0.71 (0.43, 1.16) 0.17
CDC immune 1 1 1
   Stage at visit 2 0.94 (0.73, 1.20) 0.62 0.96 (0.69, 1.34) 0.83
  3 1.02 (0.79, 1.32) 0.86 1.00 (0.70, 1.44) 0.99
Study drug at visit Placebo 1 -
  Isoniazid 1.02 (0.73, 1.43) 0.91 -
On HAART at visit No 1 1
  Yes 1.14 (0.89, 1.45) 0.30 1.08 (0.82, 1.43) 0.56
  1. † Adjusted for group, site, sex, number of people in house, age at visit, concurrent HAART, CDC immune stage at visit, CDC clinical stage at visit, time on study at visit. Two patients excluded from multivariate model due to missing information on number of people in the house and CDC immune staging at follow up.
  2. OR = odds ratio; AOR = adjusted OR; CI = confidence interval; RCCH = Red Cross War Memorial Children's Hospital; TCH = Tygerberg Children's Hospital; CDC = Centers for Disease Control and Prevention; HAART = highly active antiretroviral therapy; * P values from Wald tests