Table 2 Enzymes co-regulated at the gene and protein level by Signal Transducer and Activator of Transcription 1 (STAT1)
Pathway | Gene Symbol | Description | Function |
|---|---|---|---|
GG | ALDH1A1 | Aldehyde dehydrogenase 1 family, member A1 | Oxidation of acetaldehyde to acetate |
GG | ALDH2 | Aldehyde dehydrogenase 2 family (mitochondrial) | Oxidation of acetaldehyde to acetate |
GG | ALDOA | Aldolase A, fructose-bisphosphate | Cleavage of fructose 1,6-bisphosphate into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate |
GG | ENO1 | Enolase 1, (alpha) | Dehydration of 2-phosphoglycerate to phosphoenolpyruvate |
GG | ENO2 | Enolase 2 (gamma, neuronal) | Dehydration of 2-phosphoglycerate to phosphoenolpyruvate |
GG | ENO3 | Enolase 3 (beta, muscle) | Dehydration of 2-phosphoglycerate to phosphoenolpyruvate |
GG | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | Oxidation and phosphorylation of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate with reduction of NAD+ to NADH |
GG | GPI | Glucose phosphate isomerase | Conversion of glucose 6-phosphate to fructose 6-phosphate |
GG | LDHA | Lactate dehydrogenase A | Reduction of pyruvate to lactate with oxidation of NADH to NAD+ |
GG | LDHAL6B | Lactate dehydrogenase A-like 6B | Reduction of pyruvate to lactate with oxidation of NADH to NAD+ |
GG | LDHB | Lactate dehydrogenase B | Reduction of pyruvate to lactate with oxidation of NADH to NAD+ |
GG | PGAM1 | Phosphoglycerate mutase 1 (brain) | Conversion of 3-phosphoglycerate to 2-phosphoglycerate |
GG | PGK1 | Phosphoglycerate kinase 1 | Phosphoryl transfer from 1,3-bisphosphoglycerate to ADP with formation of 3-phosphoglycerate and ATP |
GG | PGM1 | Phosphoglucomutase 1 | Interconversion of glucose 1-phosphate and glucose 6-phosphate |
GG | PKM2 | Pyruvate kinase type 2, muscle | Phosphoryl transfer from phosphoenolpyruvate to ADP with formation of pyruvate and ATP |
GG | TPI1 | Triosephosphate isomerase 1 | Interconversion of dihydroxyacetone phosphate and glyceraldehyde 3-phosphate |
OP | ATP5A1 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle | Synthesis of ATP from ADP and inorganic phosphate |
OP | ATP5O | ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit | Synthesis of ATP from ADP and inorganic phosphate |
OP | ATP5B | ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide | Synthesis of ATP from ADP and inorganic phosphate |
OP | COX4I1 | Cytochrome c oxidase subunit IV isoform 1 | Oxidation of cytochrome C with reduction of O2 to H2O |
OP/CC | SDHA | Succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | Oxidation of succinate to fumarate with reduction of FAD+ to FADH2 |
CC | MDH2 | Malate dehydrogenase 2, NAD (mitochondrial) | Oxidation of malate to oxaloacetate with reduction of NAD+ to NADH |