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Table 2 Cox proportional hazards models for relapse-free survival using the NKI 295 patient test data set – model containing the clinical variables and multiple gene expression profiles

From: A compact VEGF signature associated with distant metastases and poor outcomes

Variable DF Estimate Standard Error Chi-Square Pr > ChiSq Hazard Ratio 95% Hazard Ratio Confidence Limits
Age 1 -0.0505 0.0174 8.4217 0.0037 0.951 0.919 0.984
ER 1 -0.5654 0.34723 2.6514 0.1035 0.568 0.288 1.122
Grade2vs1 1 0.15563 0.33471 0.2162 0.642 1.168 0.606 2.252
Grade3vs1 1 0.02327 0.36156 0.0041 0.9487 1.024 0.504 2.079
Tsize 1 0.53014 0.19935 7.0723 0.0078 1.699 1.15 2.511
node 1 0.15863 0.19203 0.6824 0.4087 1.172 0.804 1.707
Treatment 1 -0.63284 0.29747 4.526 0.0334 0.531 0.296 0.951
VEGF_3group 1 0.47637 0.1597 8.8972 0.0029 1.61 1.177 2.202
GHI 1 0.24924 0.22057 1.2769 0.2585 1.283 0.833 1.977
Gene70 1 0.6283 0.33298 3.5605 0.0592 1.874 0.976 3.6
Wound_Response 1 0.8087 0.35969 5.0549 0.0246 2.245 1.109 4.543
LumA_LumB 1 0.74421 0.36168 4.2339 0.0396 2.105 1.036 4.276
LumA_Basal 1 -0.68615 0.48782 1.9785 0.1596 0.504 0.194 1.31
LumA_Her2- enrich 1 -0.16349 0.45232 0.1306 0.7178 0.849 0.35 2.061
LumA_Normal 1 0.51006 0.37635 1.8368 0.1753 1.665 0.796 3.482
ER-regulated 1 0.02629 0.32219 0.0067 0.935 1.027 0.546 1.93
TP53-associated 1 -0.0764 0.31658 0.0582 0.8093 0.926 0.498 1.723