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Table 4 Cox proportional hazards models for relapse-free survival using the NKI 295 patient test data set – model containing the clinical variables and the VEGF-profile as a continuous variable

From: A compact VEGF signature associated with distant metastases and poor outcomes

Variable DF Estimate Standard Error Chi-Square Pr > ChiSq Hazard Ratio 95% Hazard Ratio Confidence Limits
Age 1 -0.0589 0.01639 12.906 0.0003 0.943 0.913 0.974
ER 1 0.00607 0.25196 0.0006 0.9808 1.006 0.614 1.649
Grade2vs1 1 0.82592 0.31135 7.0367 0.008 2.284 1.241 4.204
Grade3vs1 1 0.78226 0.32128 5.9284 0.0149 2.186 1.165 4.104
Tsize 1 0.31513 0.19566 2.5941 0.1073 1.37 0.934 2.011
node 1 0.3314 0.17655 3.5233 0.0605 1.393 0.985 1.969
Treatment 1 -0.61996 0.27417 5.1133 0.0237 0.538 0.314 0.921
VEGF_Continuous 1 0.43301 0.12298 12.3972 0.0004 1.542 1.212 1.962