Skip to main content

Table 5 Correlation analysis of multiple gene expression profiles linked to metastasis biology or formation compared with each other

From: A compact VEGF signature associated with distant metastases and poor outcomes

Quantized Variables Testing
Primary Signature Test Signature Ch-aquare P-value Cramer's V Fisher Exact P-value
VEGF profile MetScore 0.0002 0.272 4.80E-04
VEGF profile NKI 70-gene profile 0.0008 0.3126 3.60E-04
VEGF profile Wound Response Profile 0.0001 0.3524 3.78E-06
VEGF profile Intrinsic Subtype < 0.0001 0.4223 4.29E-11
VEGF profile hypoxia-signature < 0.0001 0.6394 1.10E-15
VEGF profile hypoxia-metagene (50:50) < 0.0001 0.5722 8.29E-12
Intrinsic Subtype MetScore 0.0054 0.2578 7.09E-04
Intrinsic Subtype Hypoxia signature < 0.0001 0.739 1.40E-20
Intrinsic Subtype VEGF profile < 0.0001 0.4223 4.29E-11
Intrinsic Subtype NKI 70-gene profile < 0.0001 0.4449 5.94E-06
Intrinsic Subtype Wound Response Profile < 0.0001 0.7389 1.56E-16
Intrinsic Subtype Hypoxia metagene (50:50) < 0.0001 0.5181 4.91E-09
Continuous Variables Testing
Primary Signature Test Signature ANOVA P -value   
VEGF profile BoneMeta 43 Up genes Average < 0.0001   
VEGF profile Breast2Lung-Average < 0.0001   
VEGF profile Snail1 < 0.0001   
VEGF profile Twist1 0.3   
VEGF profile 11 stem cell signature-Average 0.0074   
VEGF profile 6-Best-Glycolysis-Probes < 0.0001   
VEGF profile Fibroblast-line-Avg 0.7   
VEGF profile HIF1A 0.0004   
VEGF profile hypoxia-metagene (50:50) < 0.0001   
Intrinsic Subtype BoneMeta 43 Up genes Average 0.054   
Intrinsic Subtype Breast2Lung-Average 0.036   
Intrinsic Subtype Snail1 0.0002   
Intrinsic Subtype Twist1 0.2   
Intrinsic Subtype 11 stem cell signature-Average < 0.0001   
Intrinsic Subtype 6-Best-Glycolysis-Probes < 0.0001   
Intrinsic Subtype Fibroblast-line-Avg 0.012   
Intrinsic Subtype HIF1A 0.0033   
Intrinsic Subtype hypoxia-metagene (50:50) < 0.0001