Table 5 Correlation analysis of multiple gene expression profiles linked to metastasis biology or formation compared with each other

VEGF profile

MetScore

0.0002

0.272

4.80E-04

VEGF profile

NKI 70-gene profile

0.0008

0.3126

3.60E-04

VEGF profile

Wound Response Profile

0.0001

0.3524

3.78E-06

VEGF profile

Intrinsic Subtype

< 0.0001

0.4223

4.29E-11

VEGF profile

hypoxia-signature

< 0.0001

0.6394

1.10E-15

VEGF profile

hypoxia-metagene (50:50)

< 0.0001

0.5722

8.29E-12

Intrinsic Subtype

MetScore

0.0054

0.2578

7.09E-04

Intrinsic Subtype

Hypoxia signature

< 0.0001

0.739

1.40E-20

Intrinsic Subtype

VEGF profile

< 0.0001

0.4223

4.29E-11

Intrinsic Subtype

NKI 70-gene profile

< 0.0001

0.4449

5.94E-06

Intrinsic Subtype

Wound Response Profile

< 0.0001

0.7389

1.56E-16

Intrinsic Subtype

Hypoxia metagene (50:50)

< 0.0001

0.5181

4.91E-09

Continuous Variables Testing

Primary Signature

Test Signature

ANOVA P -value

VEGF profile

BoneMeta 43 Up genes Average

< 0.0001

VEGF profile

Breast2Lung-Average

< 0.0001

VEGF profile

Snail1

< 0.0001

VEGF profile

Twist1

0.3

VEGF profile

11 stem cell signature-Average

0.0074

VEGF profile

6-Best-Glycolysis-Probes

< 0.0001

VEGF profile

Fibroblast-line-Avg

0.7

VEGF profile

HIF1A

0.0004

VEGF profile

hypoxia-metagene (50:50)

< 0.0001

Intrinsic Subtype

BoneMeta 43 Up genes Average

0.054

Intrinsic Subtype

Breast2Lung-Average

0.036

Intrinsic Subtype

Snail1

0.0002

Intrinsic Subtype

Twist1

0.2

Intrinsic Subtype

11 stem cell signature-Average

< 0.0001

Intrinsic Subtype

6-Best-Glycolysis-Probes

< 0.0001

Intrinsic Subtype

Fibroblast-line-Avg

0.012

Intrinsic Subtype

HIF1A

0.0033

Intrinsic Subtype

hypoxia-metagene (50:50)

< 0.0001