Breast fibroblast derived IGF-I signature in early stage breast cancer. (A) Unsupervised hierarchical clustering of breast fibroblast derived IGF-I signature in Netherlands Cancer institute dataset. The expression values of genes in the breast fibroblast derived IGF-I signature revealed by signficant analysis of microarray were extracted from a published expression study of 295 early stage breast cancers from the Netherlands Cancer Institute (NKI). Genes are presented in rows and experiments in columns. Breast fibroblast derived IGF-I signature stratifies early breast cancer patients (NKI) into two groups with high (blue) or low (yellow) expression levels of genes representing the signature. Horizontal bar below the figure represents positive (purple) or negative (orange) ER status. (B) Relationship of expression level of genes building breast fibroblast derived IGF-I signature with distant metastasis free and overall survival. Kaplan-Meier curves representing the clinical outcomes of tumors exhibiting high (blue curve) and low (yellow curve) expression levels of the IGF-I induced signature. The upper two figures represent all patients and the bottom figure shows only patients with oestrogen receptor positive breast tumours.