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Table 1 Gene ontology terms for genes up-regulated in CCL-171 cells by insulin-like growth factor (IGF-I).

From: IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients

Gene ontology term Cluster frequency Gene frequency in background Corrected
P-value
FDR False positives
M phase 42 out of 325 genes, 12.9% 67 out of 2133 genes, 3.1% 1.84E-16 0.0% 0.0
Cell cycle phase 45 out of 325 genes, 13.8% 82 out of 2133 genes, 3.8% 1.46E-14 0.0% 0.0
Cell division 38 out of 325 genes, 11.7% 69 out of 2133 genes, 3.2% 5.07E-12 0.0% 0.0
M phase of mitotic cell cycle 32 out of 325 genes, 9.8% 52 out of 2133 genes, 2.4% 1.06E-11 0.0% 0.0
Cell cycle process 50 out of 325 genes, 15.4% 113 out of 2133 genes, 5.3% 2.13E-11 0.0% 0.0
Nuclear division 31 out of 325 genes, 9.5% 51 out of 2133 genes, 2.4% 4.65E-11 0.0% 0.0
Mitosis 31 out of 325 genes, 9.5% 51 out of 2133 genes, 2.4% 4.65E-11 0.0% 0.0
Cell cycle 57 out of 325 genes, 17.5% 143 out of 2133 genes, 6.7% 7.11E-11 0.0% 0.0
Organelle fission 31 out of 325 genes, 9.5% 52 out of 2133 genes, 2.4% 9.95E-11 0.0% 0.0
Mitotic cell cycle 39 out of 325 genes, 12.0% 86 out of 2133 genes, 4.0% 7.94E-09 0.0% 0.0
Organelle organization 67 out of 325 genes, 20.6% 217 out of 2133 genes, 10.2% 4.21E-07 0.0% 0.0
Cellular component organization 91 out of 325 genes, 28.0% 358 out of 2133 genes, 16.8% 1.78E-05 0.0% 0.0
Microtubule-based process 21 out of 325 genes, 6.5% 40 out of 2133 genes, 1.9% 2.56E-05 0.0% 0.0
Regulation of mitotic cell cycle 17 out of 325 genes, 5.2% 31 out of 2133 genes, 1.5% 2.40E-04 0.0% 0.0
Spindle organization 10 out of 325 genes, 3.1% 14 out of 2133 genes, 0.7% 2.70E-03 0.4% 0.1
Microtubule-based Movement 10 out of 325 genes, 3.1% 15 out of 2133 genes, 0.7% 0.01 0.6% 0.1
Mitotic cell cycle checkpoint 9 out of 325 genes, 2.8% 13 out of 2133 genes, 0.6% 0.01 0.6% 0.1
Regulation of cell cycle 27 out of 325 genes, 8.3% 79 out of 2133 genes, 3.7% 0.01 0.6% 0.1
Biological regulation 152 out of 325 genes, 46.8% 785 out of 2133 genes, 36.8% 0.04 0.6% 0.1
Microtubule cytoskeleton organization 12 out of 325 genes, 3.7% 24 out of 2133 genes, 1.1% 0.05 0.7% 0.1
  1. Detailed list of gene ontology terms specifically up-regulated in CCL-171 fibroblasts upon IGF-I stimulation in comparison to background file including all genes deregulated by IGF-I. Bonferroni corrected p values for of the output from GO::Termfinder for process ontology are listed.
  2. FDR, false discovery rate.