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Table 2 Gene ontology terms for genes up-regulated in breast fibroblasts by insulin-like growth factor-1 (IGF-I).

From: IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients

Gene Ontology term Cluster frequency Gene frequency in background Corrected P-value FDR False positives
M phase 36 out of 186 genes, 19.4% 175 out of 8918 genes, 2.0% 2.00E-23 0% 0.00
Cell cycle phase 37 out of 186 genes, 19.9% 223 out of 8918 genes, 2.5% 1.18E-20 0% 0.00
Cell cycle process 41 out of 186 genes, 22.0% 314 out of 8918 genes, 3.5% 4.69E-19 0% 0.00
Nuclear division 28 out of 186 genes, 15.1% 128 out of 8918 genes, 1.4% 1.64E-18 0% 0.00
Mitosis 28 out of 186 genes, 15.1% 128 out of 8918 genes, 1.4% 1.64E-18 0% 0.00
Cell cycle 46 out of 186 genes, 24.7% 425 out of 8918 genes, 4.8% 2.85E-18 0% 0.00
M phase of mitotic cell cycle 28 out of 186 genes, 15.1% 131 out of 8918 genes, 1.5% 3.21E-18 0% 0.00
Organelle fission 28 out of 186 genes, 15.1% 133 out of 8918 genes, 1.5% 4.99E-18 0% 0.00
Mitotic cell cycle 33 out of 186 genes, 17.7% 229 out of 8918 genes, 2.6% 3.30E-16 0% 0.00
Cell division 28 out of 186 genes, 15.1% 164 out of 8918 genes, 1.8% 1.88E-15 0% 0.00
Microtubule-based process 24 out of 186 genes, 12.9% 130 out of 8918 genes, 1.5% 8.42E-14 0% 0.00
Microtubule-based movement 13 out of 186 genes, 7.0% 47 out of 8918 genes, 0.5% 3.61E-09 0% 0.00
Spindle organization 10 out of 186 genes, 5.4% 27 out of 8918 genes, 0.3% 3.73E-08 0% 0.00
Cytoskeleton-dependent intracellular transport 13 out of 186 genes, 7.0% 56 out of 8918 genes, 0.6% 4.11E-08 0% 0.00
Organelle organization 44 out of 186 genes, 23.7% 737 out of 8918 genes, 8.3% 6.24E-08 0% 0.00
Chromosome segregation 10 out of 186 genes, 5.4% 41 out of 8918 genes, 0.5% 3.83E-06 0% 0.00
Microtubule cytoskeleton organization 12 out of 186 genes, 6.5% 70 out of 8918 genes, 0.8% 8.84E-06 0% 0.00
Phosphoinositide-mediated signalling 8 out of 186 genes, 4.3% 27 out of 8918 genes, 0.3% 2.32E-05 0% 0.00
Mmitotic sister chromatid segregation 7 out of 186 genes, 3.8% 22 out of 8918 genes, 0.2% 9.41E-05 0% 0.00
Sister chromatid segregation 7 out of 186 genes, 3.8% 22 out of 8918 genes, 0.2% 9.41E-05 0% 0.00
Cellular component organization 50 out of 186 genes, 26.9% 1187 out of 8918 genes, 13.3% 3.40E-04 0% 0.00
Regulation of mitotic cell cycle 10 out of 186 genes, 5.4% 72 out of 8918 genes, 0.8% 1.03E-03 0% 0.00
Second-messenger-mediated signalling 8 out of 186 genes, 4.3% 44 out of 8918 genes, 0.5% 1.36E-03 0% 0.00
Regulation of cell cycle 16 out of 186 genes, 8.6% 197 out of 8918 genes, 2.2% 1.68E-03 0% 0.00
Cytoskeleton organization 16 out of 186 genes, 8.6% 198 out of 8918 genes, 2.2% 1.80E-03 0% 0.00
Protein polymerization 6 out of 186 genes, 3.2% 23 out of 8918 genes, 0.3% 2.63E-03 0% 0.00
Positive regulation of mitosis 4 out of 186 genes, 2.2% 7 out of 8918 genes, 0.1% 2.73E-03 0% 0.00
Amino acid biosynthetic process 6 out of 186 genes, 3.2% 25 out of 8918 genes, 0.3% 4.45E-03 0% 0.00
Chromosome localization 4 out of 186 genes, 2.2% 8 out of 8918 genes, 0.1% 0.01 0% 0.00
Establishment of chromosome localization 4 out of 186 genes, 2.2% 8 out of 8918 genes, 0.1% 0.01 0% 0.00
Cell cycle checkpoint 7 out of 186 genes, 3.8% 47 out of 8918 genes, 0.5% 0.02 0% 0.04
Establishment of localization in cell 24 out of 186 genes, 12.9% 472 out of 8918 genes, 5.3% 0.02 0% 0.04
Cellular localization 25 out of 186 genes, 13.4% 507 out of 8918 genes, 5.7% 0.03 0% 0.04
DNA metabolic process 17 out of 186 genes, 9.1% 275 out of 8918 genes, 3.1% 0.03 0% 0.06
Amine biosynthetic process 6 out of 186 genes, 3.2% 35 out of 8918 genes, 0.4% 0.03 0% 0.08
Serine family amino acid biosynthetic process 3 out of 186 genes, 1.6% 5 out of 8918 genes, 0.1% 0.04 0% 0.08
  1. Detailed information and P values for single biological processes up-regulated by IGF-I in primary breast fibroblasts in comparison to background file including all genes used for significant analysis of mcroarray analysis as revealed by gene ontology term finder tool with a Bonferoni corrected P value higher than 0.05.
  2. FDR, false discovery rate.