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Table 4 DNMT3A -448A>G genotype and allele frequencies of case patients and control subjects and their association with gastric cancer (GC)

From: A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma

Genotype

GC

(n= 208)

Control subjects (n= 346)

Crude odds ratio

(95% confidence interval)

Pvalue*

 

No.

(%)

No.

(%)

  

- 448A>G

      

GG (ref.)

102

(49.0)

218

(63.0)

1.0

 

AG

75

(36.1)

118

(34.1)

1.358 (0.936-1.972)

0.107a

AA

31

(14.9)

10

(2.9)

6.625 (3.128-14.034)

0.000b

A allele

32.9

19.9

  
  1. *Chi-square test;.
  2. a versus GG genotype.
  3. b versus GG genotype.