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Table 5 Distribution of -448A>G DNMT3A genotypes and associated odds ratio (OR) in relation to age and gender in gastric cancer (GC) cases

From: A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma

Genotype

GC cases (%)

Controls (%)

OR

Pvalue

Age(years)

    

≤60

    

GG

40 (19.2)

80(23.1)

1.0

 

AG

40 (19.2)

57 (16.5)

1.404 (0.806-2.444)

0.230

AA

19 (9.1)

4(1.2)

9.500(3.029-29.796)

0.000

>60

    

GG

62 (29.8)

138(39.9)

1.0

 

AG

35 (16.8)

61 (17.6)

1.277 (0.765-2.132)

0.349

AA

12 (5.8)

6 (1.7)

4.452(1.598-12.404)

0.002

   Gender

    

Male

    

GG

70(33.7)

152(43.9)

1.0

 

AG

61(29.3)

82 (23.7)

1.615(1.045-2.498)

0.031

AA

26(12.5)

9 (2.6)

6.273(2.793-14.089)

0.000

Female

    

GG

32(15.4)

66(19.1)

1.0

 

AG

14(6.7)

36 (10.4)

0.802(0.380-1.694)

0.563

AA

5(2.4)

1 (0.3)

10.313(1.156-91.974)

0.012