Table 2 Proteins found unique to the African-American dataset that are reported to be involved in breast cancer, as annotated by Ingenuity Systems or BIOBASE.
Symbol | Entrez gene name | Location | Entrez gene ID |
|---|---|---|---|
ADAM12 | ADAM metallopeptidase domain 12 | Plasma membrane | 8038 |
ADRA2C | Adrene gic, alpha-2C-, receptor | Plasma membrane | 152 |
AKR1C1 | Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1) | Cytoplasm | 1645 |
ANK1 | Ankyrin 1, erythrocytic | Plasma membrane | 286 |
ANXA1 | Annexin A1 | Plasma membrane | 301 |
ANXA5 | Annexin A5 | Plasma membrane | 308 |
BCAS1 | Breast carcinoma amplified sequence 1 | Unknown | 8537 |
CAMKK1 | Calcium/calmodulin-dependent protein kinase kinase 1, alpha | Cytoplasm | 84254 |
CANX | Calnexin | Cytoplasm | 821 |
CASP1 | Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, convertase | Cytoplasm | 834 |
CD69 | CD69 molecule | Plasma membrane | 969 |
CDH11 | Cadherin 11, type 2, OB-cadherin (osteoblast) | Plasma membrane | 1009 |
CDR2 | Cerebellar degeneration-related protein 2, 62 kDa | Cytoplasm | 1039 |
CTSD | Cathepsin D | Cytoplasm | 1509 |
DAB2 | Disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | Plasma membrane | 1601 |
DECR1 | 2,4-Dienoyl CoA reductase 1, mitochondrial | Cytoplasm | 1666 |
DFNA5 | Deafness, autosomal dominant 5 | Unknown | 1687 |
DLC1 | Deleted in liver cancer 1 | Cytoplasm | 10395 |
EDNRB | Endothelin receptor type B | Plasma membrane | 1910 |
EEF1A1 | Eukaryotic translation elongation factor 1 alpha 1 | Cytoplasm | 1915 |
ERBB4 | V-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) | Plasma membrane | 2066 |
FBLN1 | Fibulin 1 | Extracellular space | 2192 |
GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | Cytoplasm | 2597 |
GRIN2D | Glutamate receptor, ionotropic, N-methyl d-aspartate 2D | Plasma membrane | 2906 |
GSN | Gelsolin (amyloidosis, Finnish type) | Extracellular space | 2934 |
HSPB1 | Heat shock 27 kDa protein 1 | Cytoplasm | 3315 |
IGF1R | Insulin-like growth factor 1 receptor | Plasma membrane | 3480 |
KDR | Kinase insert domain receptor (a type III receptor tyrosine kinase) | Plasma membrane | 3791 |
LTF | Lactotransferrin | Extracellular space | 4057 |
MET | Met proto-oncogene (hepatocyte growth factor receptor) | Plasma membrane | 4233 |
MMP14 | Matrix metallopeptidase 14 (membrane-inserted) | Extracellular space | 4323 |
MUC6 | Mucin 6, oligomeric mucus/gel-forming | Extracellular space | 4588 |
NLRP1 | NLR family, pyrin domain containing 1 | Cytoplasm | 22861 |
ORM1 | Orosomucoid 1 | Extracellular space | 5004 |
PDGFRB | Platelet-derived growth factor receptor, beta polypeptide | Plasma membrane | 5159 |
PLXNA1 | Plexin A1 | Plasma membrane | 5361 |
POR | P450 (cytochrome) oxidoreductase | Cytoplasm | 5447 |
PTPRG | Protein tyrosine phosphatase, receptor type, G | Plasma membrane | 5793 |
ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | Cytoplasm | 6093 |
S100A9 | S100 calcium binding protein A9 | Cytoplasm | 6280 |
SERPINA3 | Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase), member 3 | Extracellular space | 12 |
SERPINB5 | Serpin peptidase inhibitor, clade B (ovalbumin), member 5 | Extracellular space | 5268 |
SOD1 | Superoxide dismutase 1, soluble | Cytoplasm | 6647 |
SOD2 | Superoxide dismutase 2, mitochondrial | Cytoplasm | 6648 |
SYK | Spleen tyrosine kinase | Cytoplasm | 6850 |
TAGLN | Transgelin | Cytoplasm | 6876 |
TJP1 | Tight junction protein 1 (zona occludens 1) | Plasma membrane | 7082 |
TXNRD1 | Thioredoxin reductase 1 | Cytoplasm | 7296 |