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Table 1 Summary of studies using BNP or NTproBNP for ris stratification of AMI

From: Biomarkers in acute myocardial infarction

Study Pop N Endpoints Thresholds Odds ratio or Hazard Ratio Ref
ACS-TIMI16 2,525 Death (30 day, 10 months) HF(10 months) MI (10 months) Quartiles BNP > 80 pg/ml 1, 3.8, 4.0, 5.8 Approximately 2.7 Approximately 2 [28]
AMI 70 Death (18 months) Median (>59 pg/ml) Approximately 2.5 [29]
AMI-CONSENSUS 131 Death (one year) 75th centile BNP 33.3 pmol/L Approximately 1.36 [30]
ACS 609 Death Median 2.4 [37]
NSTEACS 1,483 Death (in hosp) (180 days) BNP > 586 pg/ml (1.7) (1.67) [38]
FRISC-II 2,019 Death Top Tertile 4.1(invasive) vs 3.5(non-invasive) [36]
TACTICS-TIMI18 1,676 Death (six months) HF (30 days) BNP > 80 pg/ml OR 3.3 OR 3.9 [35]
ACS 1,033 Death (30 day) (six months) Quartiles (2.24) (1.84) [34]
AMI 473 Death Median OR 3.82 [39]