Figure 3From: Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways The inflammatory and oxidative and nitrosative (IO&NS) pathophysiology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). COX-2 = cyclo-oxygenase 2; iNOS = inducible nitric oxide synthase; PUFA = polyunsaturated fatty acids; NFκB = nuclear factor κB.Back to article page