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Table 2 Cumulative probability of human papillomavirus (HPV) acquisition/reactivation among HIV-positive and HIV-negative women with and without cryotherapy

From: Reduced acquisition and reactivation of human papillomavirus infections among older women treated with cryotherapy: results from a randomized trial in South Africa

  Cumulative no. with a newly detected HPV infection (cumulative%)  
  6 months 12 months 24 months 36 months Pvalue for log-rank test
HIV-negative women      
Total sample:      
   Cryotherapy arm (n = 271) 15 (5.5) 21 (7.9) 25 (9.7) 28 (11.2) 0.0004
   Control arm (n = 269) 17 (6.3) 30 (11.5) 45 (18.0) 59 (24.8)  
Sexual activity reported during 1 month prior to enrolment or at 1 or 6 months after enrollment:      
   Cryotherapy arm (n = 238)a 13 (5.5) 18 (7.7) 22 (9.7) 25 (11.3) 0.002
   Control arm (n = 236)b 16 (6.8) 27 (11.8) 42 (19.4) 56 (27.2)  
No sexual activity reported during 1 month prior to enrollment and at 1 and 6 months after enrollment:      
   Cryotherapy arm (n = 31)a 2 (6.5) 3 (10.4) 3 (10.4) 3 (10.4) 0.96
   Control arm (n = 29)b 1 (3.5) 3 (10.3) 3 (10.3) 3 (10.3)  
HIV-positive women      
Total sample:      
   Cryotherapy arm (n = 38) 9 (23.7) 16 (42.1) 19 (50.8) 20 (53.7) 0.8
   Control arm (n = 34)c 7 (20.6) 14 (42.8) 15 (46.6) 16 (50.5)  
Sexual activity reported during 1 month prior to enrollment or at 1 or 6 months after enrollment:      
   Cryotherapy arm (n = 33) 8 (24.2) 12 (36.4) 15 (46.4) 16 (49.8) 0.65
   Control arm (n = 29)c 7 (24.1) 14 (49.4) 15 (54.0) 15 (54.0)  
No sexual activity reported during 1 month prior to enrollment and at 1 and 6 months after enrollment:      
   Cryotherapy arm (n = 5) 1 (20.0) 4 (80.0) 4 (80.0) 4 (80.0) 0.08
   Control arm (n = 3) 0 0 0 0  
  1. aExcludes two women who could not be classified as either sexual active or inactive during the first 6 months of the study.
  2. bExcludes four women who could not be classified as either sexual active or inactive during the first 6 months of the study.
  3. cExcludes two women who could not be classified as either sexual active or inactive during the first 6 months of the study.