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Table 3 Relationship between the hypoxia inducible factor 1α (HIF-1α) splice variant's expression levels (normalised copy numbers) and clinicopathological factors or microvessel density in tumour tissue specimens from 53 breast cancer patients

From: Hypoxia inducible factor 1α gene (HIF-1α) splice variants: potential prognostic biomarkers in breast cancer

Variable N Total HIF-1α,
mean (SD)
Pvalue HIF-1α TAG,
mean (SD)
Pvalue HIF-1α 736,
mean (SD)
Pvalue
Lymph node status:        
Negative 25 10.0 (9.0) NS 10.9 (10.9) 0.037 0.19 (0.29) NS
Positive 22 12.8 (7.8)   21.1 (19.2)   0.26 (0.28)  
Pathological tumour size:        
< 20 mm 28 10.2 (8.3) NS 12.4 (13.2) NS 0.17 (0.26) NS
≥ 20 mm 25 11.8 (8.3)   17.9 (17.4)   0.25 (0.28)  
Tumour grade:        
1/2 vs 35 9.2 (7.7) 0.048 11.8 (12.3) 0.048 0.19 (0.30) NS
3 17 14.6 (8.7)   21.5 (19.4)   0.23 (0.20)  
Peritumoural vascular invasion:        
Absent 12 8 (9) 0.028 9.6 (10.1) NS 0.19 (0.36) NS
Present 40 11.9 (8.1)   16.6 (16.6)   0.20 (0.24)  
OR status:        
Negative 16 14.2 (7.3) 0.024 20.8 (11.9) 0.005 0.25 (0.19) 0.06
Positive 32 10 (8.8)   12.7 (17.1)   0.20 (0.31)  
PgR status:        
Negative 24 11.8 (7.3) NS 20.08 (17.8) 0.033 0.23 (0.19) 0.077
Positive 26 10.8 (9.4)   11.3 (12.3)   0.2 (0.34)  
Tumour microvessel density (low vs high)    NS   NS   NS
  1. Because of missing data, the numbers do not always add up to 53. Expression levels of HIF-1α 516and HIF-1α 557mRNA were not included in statistical analyses because of their very low levels (mean normalised copy numbers < 0.1).
  2. NS = non-significant; OR = oestrogen receptor; PgR = progesterone receptor.