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Table 2 Antiemetic agents and supposed dosage in hyperemesis gravidarum, adapted from references [13, 62, 98]

From: Managing hyperemesis gravidarum: a multimodal challenge

Food and Drug Admnistration category Medication Administration Suggested dosage
A Pyridoxine (vitamin B6) Oral 20 mg 3 × per day (max. dose: 200 mg per day)
  Doxylamine Oral 25 mg at night and 12.5 mg in the morning accompanied by 10 mg of pyridoxine (maximum dose: 80 mg per day)
B Ondansetron Oral/intravenously (IV) 4-8 mg 2-3× per day/2-4 mg every 6-8 h or 8 mg every 12 h IV
  Metoclopramide Oral 5-10 mg 3-4 × per day
  Meclizine Oral/rectal 25-100 mg 2-4 × per day/1 × per day
  Diphenhydramine Oral/IV 25-50 mg every 6-8 h
  Dimenhydrinate Oral/IV/rectal 50 mg 3-4× per day/62 mg 2× per day/1-3× per day
C Promethazine Oral/IV 12.5-25 mg up to 6 × per day
  Prochlorperazine Rectal 25 mg per day or 2× per day
  Prednisolone Oral 40-60 mg per day reducing by half every 3 days
- Ginger Oral (biscuits, confectionary, crystals, powder, tablets, capsules, fresh ginger) Up to 1 g per day in divided doses