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Table 2 Clinical characteristics of the study sample.

From: An evaluation of inflammatory gene polymorphisms in sibships discordant for premature coronary artery disease: the GRACE-IMMUNE study

  Unaffected Affected   
Risk factor N(%) N(%) Univariate
P-value *
Multivariable
OR†
Total sample 1545 (100) 1154 (100) - -
Male sex 630 (40.8) 873 (75.7) <0.0001 4.71 (3.65, 6.08)
Diabetes mellitus 62 (4.0) 117 (10.1) <0.0001 1.63 (1.00, 2.66)
Hypertension 391 (25.3) 522 (45.2) <0.0001 1.99 (1.52, 2.60)
Hypercholesterolaemia 454 (29.4) 945 (81.9) <0.0001 10.70 (8.11, 14.11)
Ever smoked 856 (55.4) 849 (73.6) <0.0001 1.72 (1.32, 2.25)
BMI Mean (SD)
27.16 (4.62)
Mean (SD)
27.74 (4.05)
0.0002 1.00 (0.97, 1.04)
  1. * Univariate conditional logistic regression for binary factors and linear regression clustered by family for body mass index (BMI)
  2. † Odds ratio (OR) and 95% confidence intervals from multivariable conditional logistic regression analysis including all six factors
  3. SD: standard deviation
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