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Table 3 Tests of association between SNPs and CAD using FBAT.

From: An evaluation of inflammatory gene polymorphisms in sibships discordant for premature coronary artery disease: the GRACE-IMMUNE study

Chromosome Gene SNP RS number MAF P-value *
1p32-p31 VCAM1 T707C 1041163 0.16 0.39
1q21-24 SELP G40A 6131 0.18 0.84
   G75271T 6133 0.14 0.67
1q22-q25 SELE A153C 5361 0.11 0.33
1q31-32 IL10 C8700A 1800872 0.24 0.29
2q12-q21 IL1α C549T 1800587 0.31 0.08
2q14 IL1β C4336T 1143634 0.26 0.58
   C1423T 16944 0.34 0.49
2q33 CTLA4 C875T 5742909 0.10 0.34
2q33 CTLA4 A1241G 231775 0.40 0.68
3p21 CCR2 G46295A 1799864 0.08 0.88
3p21 CCR5 Wt/del 580-611 333 0.14 0.72
   G59029A 1799987 0.44 0.33
3p21.3 CCR3 C320T 5742906 0.01 - †
3p26-p24 IL5RA G482A 2290608 0.28 0.10
4q12-q13 GC G35706T 7041 0.44 0.50
  GC C35717A 4588 0.29 0.21
5q22-32 CD14 C2232T 2569190 0.47 0.63
5q23-q31 IL4 C582T 2243250 0.14 0.66
5q31 IL13 C4045T 1295686 0.20 0.78
5q31 TCF7 C883A 5742913 0.12 0.35
5q31.1 TCF7 A383T 25882 0.14 0.49
5q31.1 CSF2 T2600C 244656 0.22 0.16
5q31-q32 ADRB2 A1633G 1042713 0.37 0.91
   C1666G 1042714 0.42 0.37
   C2078T 1800888 0.02 - †
5q31-q35 IL9 C4244T 2069885 0.13 0.01 (T)
5q35 LTC4S A620C 730012 0.31 0.22
6p21.3 LTA A1069G 909253 0.39 0.60
  TNF G3787A 1800629 0.21 0.34
   G3857A 361525 0.07 0.99
7p21-p15 IL6 G589C 1800796 0.06 0.33
   G987C 1800795 0.43 0.38
7q35-q36 NOS3 A498G 1800779 0.40 0.05 (G)
   G7002T 1799983 0.36 0.67
9q32-q34 C5 A2416G 17611 0.44 0.04 (G)
10q11.1 SDF1 G880A 1801157 0.20 0.84
11q11-qter UGB G587A 3741240 0.36 0.65
11q13 FCERB1 A7297G 569108 0.03 0.48
12q13.1 VDR T12022C 2228570 0.40 0.77
   G45082A 1544410 0.42 0.61
16p11.2-p12.1 IL4R A398G 1805010 0.46 0.56
   T1682C 1805015 0.20 0.01 (C)
   A1902G 1801275 0.25 0.04 (G)
17q11.2-q12 NOS2A C231T 1137933 0.23 0.98
17q21.1-q21.2 SCYA11 G361A 3744508 0.19 0.04 (G)
   G1169A 4795895 0.20 0.47
19q13.1 TGFB1 C629T 1800469 0.27 - ‡
19p13.2 ICAM1 A120T 5491 0.001 - ‡
   G657A 1799969 0.12 0.43
19p13.3-p13.2 C3 C364G 2230199 0.24 0.39
  1. * In parenthesis after the P-value: the allele associated with an increased disease risk.
  2. † Number of informative families below 50.
  3. ‡ Not in Hardy-Weinberg equilibrium.
  4. MAF, minor allele frequency; SNP, single nucleotide polymorphism; CAD, coronary artery disease.
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