An evaluation of inflammatory gene polymorphisms in sibships discordant for premature coronary artery disease: the GRACE-IMMUNE study

Table 4 Haplotype association to CAD, CAD before age 50 (CAD50) or MI.

Gene	SNP	Position *	LD†	Hap^‡	Freq^§	P_CAD	P_MI	P_CAD50
IL1α	C549T	113259431		CCC	0.41	0.006 (+)	0.01 (+)	0.0002 (+)
			0.78	CCT	0.26	0.60	0.96	0.32
IL1β	C4336T	113306861		CTC	0.17	0.30	0.06	0.31
			0.67	TCC	0.06	0.08	0.30	0.08
IL1β	C1423T	113311338		TCT	0.04	0.45	-	0.37
				CTC	0.03	0.69	-	-
				TTT	0.02	-	-	-
				CTT	0.01	-	-	-
				All (7df)	-	0.13	0.25	0.02
NOS3	A498G	150320876		AG	0.50	0.77	0.84	0.63
			0.47	GT	0.23	0.24	0.32	0.40
NOS3	G7002T	150327044		GG	0.16	0.16	0.11	0.36
				AT	0.11	0.009 (-)	0.005 (-)	0.15
				All (3df)	-	0.04	0.03	0.39
SCYA11	G361A	29637007		GG	0.66	0.05 (+)	0.10	0.02 (+)
			1.00	GA	0.18	0.84	0.73	0.29
SCYA11	G1169A	29635559		AG	0.16	0.02 (-)	0.09	0.06
				AA	0.00	-	-	-
				All (2df)	-	0.05	0.17	0.06
IL4R	A398G	27263704		ATA	0.45	0.16	0.36	0.15
			0.37	GTA	0.33	0.44	0.46	0.63
IL4R	T1682C	27281681		GCG	0.11	0.04 (+)	0.24	0.56
			1.00	ACG	0.06	0.22	0.49	0.20
IL4R	A1902G	27281901		ATG	0.03	0.91	0.60	0.03 (+)
				GTG	0.02	-	-	-
				GCA	0.002	-	-	-
				ACA	0.001	-	-	-
				All (7df)	-	0.88	0.41	0.17

*Physical position (base pairs) from NCBI dbSNP build 128.
† Absolute value of the linkage disequilibrium (LD) coefficient D' between consecutive single nucleotide polymorphisms (SNPs).
‡ Results only shown for haplotypes having a number of informative families >50.
§Haplotype frequencies estimated in the total sample.
+ (-), Haplotype associated with increased (decreased) disease risk; CAD, coronary artery disease; MI, myocardial infarction; SNP, single nucleotide polymorphism.

ISSN: 1741-7015