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Table 4 Haplotype association to CAD, CAD before age 50 (CAD50) or MI.

From: An evaluation of inflammatory gene polymorphisms in sibships discordant for premature coronary artery disease: the GRACE-IMMUNE study

Gene SNP Position * LD† Hap Freq§ P_CAD P_MI P_CAD50
IL1α C549T 113259431   CCC 0.41 0.006 (+) 0.01 (+) 0.0002 (+)
    0.78 CCT 0.26 0.60 0.96 0.32
IL1β C4336T 113306861   CTC 0.17 0.30 0.06 0.31
    0.67 TCC 0.06 0.08 0.30 0.08
IL1β C1423T 113311338   TCT 0.04 0.45 - 0.37
     CTC 0.03 0.69 - -
     TTT 0.02 - - -
     CTT 0.01 - - -
     All (7df) - 0.13 0.25 0.02
NOS3 A498G 150320876   AG 0.50 0.77 0.84 0.63
    0.47 GT 0.23 0.24 0.32 0.40
NOS3 G7002T 150327044   GG 0.16 0.16 0.11 0.36
     AT 0.11 0.009 (-) 0.005 (-) 0.15
     All (3df) - 0.04 0.03 0.39
SCYA11 G361A 29637007   GG 0.66 0.05 (+) 0.10 0.02 (+)
    1.00 GA 0.18 0.84 0.73 0.29
SCYA11 G1169A 29635559   AG 0.16 0.02 (-) 0.09 0.06
     AA 0.00 - - -
     All (2df) - 0.05 0.17 0.06
IL4R A398G 27263704   ATA 0.45 0.16 0.36 0.15
    0.37 GTA 0.33 0.44 0.46 0.63
IL4R T1682C 27281681   GCG 0.11 0.04 (+) 0.24 0.56
    1.00 ACG 0.06 0.22 0.49 0.20
IL4R A1902G 27281901   ATG 0.03 0.91 0.60 0.03 (+)
     GTG 0.02 - - -
     GCA 0.002 - - -
     ACA 0.001 - - -
     All (7df) - 0.88 0.41 0.17
  1. *Physical position (base pairs) from NCBI dbSNP build 128.
  2. † Absolute value of the linkage disequilibrium (LD) coefficient D' between consecutive single nucleotide polymorphisms (SNPs).
  3. ‡ Results only shown for haplotypes having a number of informative families >50.
  4. §Haplotype frequencies estimated in the total sample.
  5. + (-), Haplotype associated with increased (decreased) disease risk; CAD, coronary artery disease; MI, myocardial infarction; SNP, single nucleotide polymorphism.
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