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Figure 3 | BMC Medicine

Figure 3

From: Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety

Figure 3

Sleep latency during the treatment period. Mixed Effect Model for Repeated Measures (MMRM) predicted mean values (mean + standard error of mean) for sleep latency from the sleep diary, at baseline and weeks 3-29 of the double blind treatment periods, in those aged 65-80 years. Asterisks denote significant difference between prolonged release melatonin and placebo groups (*P < 0.05 ** P < 0.01). Numbers of patients analysed in each treatment time point are depicted

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