Figure 3From: Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety Sleep latency during the treatment period. Mixed Effect Model for Repeated Measures (MMRM) predicted mean values (mean + standard error of mean) for sleep latency from the sleep diary, at baseline and weeks 3-29 of the double blind treatment periods, in those aged 65-80 years. Asterisks denote significant difference between prolonged release melatonin and placebo groups (*P < 0.05 ** P < 0.01). Numbers of patients analysed in each treatment time point are depictedBack to article page