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Figure 4 | BMC Medicine

Figure 4

From: Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety

Figure 4

Time of going to bed during the treatment period. MMRM-predicted mean values (mean + standard error of mean) for time going to bed (hours relative to midnight) from the sleep diary at baseline and weeks 3-29 of the double blind treatment periods, Intention to Treat (ITT) 65-80 population. Asterisks denote significant difference between prolonged release melatonin and placebo groups (*P < 0.05 ** P < 0.01). Numbers of patients analysed in each treatment time point are depicted.

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