Table 3 Effects of 3 weeks treatment with prolonged release melatonin (PRM) and placebo on sleep diary-recorded sleep latency in the low excretors and the elderly patients.
| Â | Treatment | Treatment effect difference PRM - placebo; (95% confidence interval) | Pvalue* effect PRM versus placebo | |
|---|---|---|---|---|
| Â | PRM | Placebo | Â | Â |
Low excretor population | Â | Â | Â | Â |
N | 86 | 86 | Â | Â |
Baseline: mean (SD) | 74.1 (54.9) | 75.5 (58.5) | Â | Â |
Treatment: mean (SD) | 65.1 (59.9) | 66.5 (51.6) | Â | Â |
Change from baseline: mean (SD) | -9.0 (50.5) | -9.0 (48.7) | -0.6 (-14.0, 12.7) | 0.924 |
65-80 year population | Â | Â | Â | Â |
N | 137 | 144 | Â | Â |
Baseline: mean (SD) | 76.7 (63.7) | 72.5 (51.4) | Â | Â |
Treatment: mean (SD) | 57.6 (51.8) | 70.9 (54.0) | Â | Â |
Change from baseline: mean (SD) | -19.1 (47.3) | -1.7 (47.8) | -15.6 (-25.3, -6.0), | 0.002 |