Blood cell gene expression associated with cellular stress defense is modulated by antioxidant-rich food in a randomised controlled clinical trial of male smokers

Table 7 Regulation of stress relevant gene sets comparing the intervention groups to the controls with regard to changes in gene expression (FDR ≤ 5%)

		Number of Upregulated Gene Sets
		Antioxidant-Rich Diet Group		Kiwifruit Group
GSEA Gene Set Collections ¹	Number of Gene Sets in Collection ²	Up	Down	Up	Down
DNA and repair	61	15	0	13	0
Hypoxia*	33	4	0	1	0
Apoptosis	206	11	0	4	0
Cytokine*	164	1	0	0	0
Interleukin*	98	1	0	1	0
Immune* and response	62	1	0	1	1
Inflammation	7	1	0	0	0
Stress	91	6	0	0	0
Stress and response	51	4	0	0	0
Oxidative and stress	32	2	0	0	0
C3TFT³	582	13	4	3	0

¹Collections of gene sets were obtained using a gene set browser from the Broad Institute web site http://www.broad.mit.edu/gsea/ defined by the listed keywords. For some keywords we used truncated search terms as indicated by *.
²Number of gene sets passing the gene set size filter.
³The C3 TFT gene set collection consists of gene sets grouped by common transcription factor binding sites.

ISSN: 1741-7015