Blood cell gene expression associated with cellular stress defense is modulated by antioxidant-rich food in a randomised controlled clinical trial of male smokers

Table 8 Regulation of stress relevant gene sets comparing pre and post intervention gene expression within each group (FDR ≤ 5%)

GSEA Gene Set Collections	Number of up regulated Gene Sets
	Control Group		Kiwifruit Group		Antioxidant-Rich Diet Group
	Pre	Post	Pre	Post	Pre	Post
DNA and repair (61)	2	0	0	10	0	20
Hypoxia* (33)	0	0	0	2	0	3
Apoptosis (209)	1	3	0	21	0	30
Cytokine* (164)	0	3	0	9	0	8
Interleukin* (98)	1	1	0	10	0	2
Immune* and response (62)	0	2	0	11	0	6
Inflammation (7)	0	0	0	2	0	0
Stress and response (51)	0	1	0	0	0	8
Stress (91)	0	0	0	0	0	11
Oxidative and stress (32)	0	0	0	0	0	1
C3TFT (582)	0	0	1	0	0	45

¹Collections of gene sets were obtained using a gene set browser from the Broad Institute website http://www.broad.mit.edu/gsea/ defined by the listed keywords. For some keywords we used truncated search terms as indicated by *.
²Number of gene sets in each collection passing the gene set size filter is given in parentheses.
³The C3 TFT gene set collection consists of gene sets grouped by common transcription factor binding sites.

ISSN: 1741-7015