Figure 1
From: MicroRNAs: exploring a new dimension in the pathogenesis of kidney cancer
The complex involvement of microRNAs (miRNAs) in tumourigenesis. (A) Dysregulated miRNAs can have an oncogenic or tumour suppressor effect by inhibiting the protein production of their tumour suppressor or oncogenic targets, respectively. (B) Some miRNAs can be downstream targets of oncogenic of tumour suppressor genes, leading to their subsequent dysregulation and contribution to malignancy. (C) miRNA dysregulation can also be due to defective processing, mutations or epigenetic aberrations. TSG: tumour suppressor genes