The endogenous soluble VEGF receptor-2 isoform suppresses lymph node metastasis in a mouse immunocompetent mammary cancer model

Table 1 Multiplicity of any category of metastasis^a)

				Average No. of organs with metastasis except for lymph nodes^b)
Groups	Number of mice examined	Total no. of organs with metastasis	Average no. of organs with metastasis/mouse^b)	Lungs	Ovaries	Kidneys	Adrenals	Others
pVec	9	156	16.3 ± 3.3	2.0 ± 0.0	1.9 ± 0.3	1.6 ± 0.5	1.3 ± 0.9	0.0 ± 0.0
pesVEGFR-2	10	106	9.9 ± 4.1**	1.5 ± 0.8	1.8 ± 0.6	1.1 ± 1.0	1.6 ± 0.8	0.1 ± 0.3^c)
pEndo	9	6	0.7 ± 1.1**†	0.0 ± 0.0**†	0.0 ± 0.0 **†	0.0 ± 0.0**†	0.3 ± 0.7 *†	0.1 ±0.3^d)

*P < 0.05; **P < 0.01 as compared with pVec values.
†P < 0.01 as compared with pesVEGFR-2 values.
a) With respect to bilateral organs, one in unilateral metastasis and two in bilateral metastasis were counted.
b) Values are mean ± SD.
c) Metastasis to uterus.
d) Metastasis to subcutis.

ISSN: 1741-7015