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Table 1 An overview of the reported cases of extended maternal somatic support after brain death (BD) including neonatal outcomes*

From: One life ends, another begins: Management of a brain-dead pregnant mother-A systematic review-

Study Year/
country
Age of mother (yr) Cause
of
BD
Gestational age
at BD
(wk)
Duration of life support (days) Maternal
medical
complications
Indication
for
delivery
Gestational age
at delivery
(wk)
Mode
of
delivery
Neonatal
outcome
Organ
procurement
Transplant
outcome
Dillon et al. [48] 1982/
USA
24 Meningitis 23 24 Thermovariability,
DI
Fetal distress 26 C/S Female, 930 gr,
Apgar 8/8, IRDS
No -
Heikkinen et al. [49] 1985/
Finland
31 ICH
SAH
21 71 Thermovariability, pneumonia, hypotension, DI, bacteremia, panhypopituitarism Maternal
blood pressure fluctuation
31 C/S Male, 1600 gr,
Apgar 6/7,
IRDS
Normal at 8 mo.
No -
Field et al.
[14]
1988/
USA
27 CNS mass 22 63 Thermovariability, hypotension, panhypopituitarism, DI, ARDS, UTI, bacteremia Septicemia,
Growth retardation
31 C/S Male, 1440 gr
Apgar 8/8,
IRDS,
normal at 18 mo.
No -
Bernstein et al. [33] 1989/
USA
30 Traumatic brain injury 15 107 Thermovariability, panhypopituitarism, pneumonia,
DI
Suspicious for
fetal distress
32 C/S Male, 1555 gr
Apgar 6/9,
Mild hyperbilirubinemia, Normal at 11 mo.
No -
Antonini et al.
[50]
1992/
Italy
25 ICH 15 49 Panhypopituitarism,
Pneumonia
UTI,
Hemodynamic instability
Hyperglycemia
anemia
Maternal death due to progressive hypotension Not applicable Not
applicable
Intrauterine death No -
Nettina et al. [51] 1993/
USA
31 ICH 27 44 hypothermia; hypotension; decubitus ulcer,
DI, pneumonia
Maternal hypotension 33 C/S Male, 2083 gr
Apgar 9
Yes N.A.
Anstotz
[52]
1993/
Germany
18 Accident 13 38 Severe infection Not applicable Not applicable Not
applicable
Spontaneous abortion
at 19 weeks
(autopsy refused)
No -
Beguin
[53]
1993/
Switzerland
20 ICH 20 3 No complication Not applicable Not applicable Not applicable Intrauterine death Yes N.A.
Wuermeling
[54]
1994/
Germany
18 Traffic accident 14 N.A infection N.A. N.A. N.A. Intrauterine death N.A. -
Iriye et al.
[55]
1995/
USA
35 ICH
after cocaine
30 2 hypotension Maternal
blood pressure fluctuation
30 C/S Male, 1610gr,
Apgar 7/8
No -
Vives et al.
[56]
1995/
Spain
25 Meningitis 27 1,5 Hypotension,
sepsis,
DIC,
cardiac arrhythmia
Maternal hypotension 27 C/S Male, 1150 gr,
Apgars 7/10,
IRDS,
normal at 14 mo.
No -
Catanzarite et al. [32] 1997/
USA
25 ICH 25 25 Hypotension, ARDS, DI, panhypopituitarism, pneumonia, Fetal distress 28 C/S Male, 1315 gr
Apgar 3/7
fungemia
No -
Lewis et al.
[42]
1997/
USA
20 SAH 25 54 Hypotension, DI
bacteremia,
Sufficient fetal
lung maturity
32 C/S Not available Yes No complication after 1 year
Suddaby et al.
[2]
1998/
USA
Range from
15 to 45 (11 cases)
5 cases:
ICH
1 case: Hematoma
1 case: Aneurysm
1 case:
Amniotic embolus
1 case:
Glioblastoma
1 case:
Cardiac arrest
1 case:
Gunshot
Range from
2 to 40
N.A Hypotension
DI
Anemia
Hypernatremia
Hyperglycemia
Hypocalcemia
hyperchloremia
N.A N.A N.A N.A In five mothers Of 25 donated organs (5 heart, 5 liver,
10 kidney,
5 pancreas), only one liver and one pancreas graft lost.
Spike
[57]
1999/
USA
20 ICH 16 100 Panhypopituitarism, DI, Thermovariability
Hypotension
Unusual pattern of the placenta in ultrasound 31 C/S Male, 1440gr
Apgar 8/8
No -
Beca et al.
[58]
1999/
Chile
26 ICH 17 5 Hemodynamic instability
Fiber
Maternal death due to resistance
hypotension
Not applicable Not applicable Intrauterine death No -
Lane et al.
[59]
2004/
Ireland
26 Cerebral venous sinus thrombosis 13 8 DI,
pneumonia,
Hyper- and hyponatraemia
Not applicable Not applicable Not applicable Intrauterine death
at 14 weeks
Yes N.A.
Hussein et al.
[60]
2006/
UK
33 ICH 26 14 Hypertension, bradycardia,
Chest infection,
Hyperglycemia,
serum cortisol reduced
Progressive oligohydraminos 28 C/S Male, 1285 gr,
breathing difficulties
Normal at 24 mo.
No -
Souza et al.
[61]
2006/
Brazil
40 ICH 25 25 Panhypopituitarism, hyperglycemia DI, hypotension, bradycardia, hypothermia, pneumonia, Progressive oligohydraminos,
brain sparring
29 C/S Male, 815 gr
Apgars:9/10
Normal at 3 mo.
Yes N.A.
Mejia et al.
[62]
2008/
Argentina
29 ICH 17 56 DI
Panhypopituitarism,
Pneumonia
UTI,
Hemodynamic instability
Maternal hypotension
&
Cardiac arrest
25 C/S 450 gr
Premature Birth complication, Candida infection
Died at day 30
No -
  1. *ICH, intracranial hemorrhage; SAH, subarachnoid hemorrhage; DI, diabetes insipidus; ARDS, acute respiratory distress syndrome; UTI, urinary tract infection; C/S, cesarean section; IRDS, infant respiratory distress syndrome; N.A: not available.