Table 2 Top 10 differentially methylated CpG sites and the CpG site showing the largest difference.
From: Obesity related methylation changes in DNA of peripheral blood leukocytes
Gene | More significant CpG site | Second CpG site | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
ID | Dis. to TSS | Average Case/Con. (%) | Difference (%) | P | FDR | ID | Dis. to TSS | Average Case/Con. (%) | Difference (%) | P | |
UBASH3A | 13517 | -156 | 45.6/35.5 | 10.1 | 5.00 × 10-6 | 0.14 | 146 | 52 | 45.6/37.7 | 7.9 | 0.145 |
CTNND1 | 6160 | -431 | 57.4/70.2 | -12.8 | 2.00 × 10-5 | 0.20 | 18016 | 415 | 19.7/21.5 | -1.8 | 0.353 |
TRIM3 | 17029 | -348 | 6.74/9.28 | -2.54 | 2.40 × 10-5 | 0.20 | 19207 | -331 | 12.5/16.2 | -3.7 | 0.035 |
CTSZ* | 23241 | -292 | 13.6/21.0 | -7.40 | 4.40 × 10-5 | 0.24 | 1644 | -592 | 17.4/25.6 | -8.2 | 0.001 |
TRAF5 | 10097 | -319 | 69.7/58.0 | 11.7 | 4.50 × 10-5 | 0.24 | 25786 | 77 | 1.90/1.79 | 0.1 | 0.738 |
HIPK3 | 25599 | 390 | 51.5/64.9 | -13.4 | 6.50 × 10-5 | 0.26 | 5514 | 314 | 26.6/35.0 | -8.4 | 0.006 |
DPCR1 | 20918 | -46 | 62.5/70.2 | -7.70 | 6.90 × 10-5 | 0.26 | 4703 | -906 | 72.4/73.0 | -0.6 | 0.709 |
HIF3A | 2879 | 153 | 5.35/2.97 | 2.38 | 1.08 × 10-4 | 0.34 | 7009 | -1445 | 57.1/63.0 | -5.9 | 0.091 |
NOTCH4 | 5969 | -51 | 59.1/68.5 | -9.40 | 1.15 × 10-4 | 0.34 | 14700 | 4 | 19.3/23.6 | -4.3 | 0.078 |
CDH5 | 8829 | -243 | 27.2/36.5 | -9.20 | 1.75 × 10-4 | 0.44 | 22286 | 36 | 72.5/81.3 | -8.8 | 0.012 |
CREB3L3 | 23739 | 42 | 9.63/36.7 | -27.1 | 1.78 × 10-3 | 0.59 | 13445 | -26 | 5.74/25.8 | -20.1 | 0.004 |