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Table 2 Top 10 differentially methylated CpG sites and the CpG site showing the largest difference.

From: Obesity related methylation changes in DNA of peripheral blood leukocytes

Gene More significant CpG site Second CpG site
  ID Dis. to TSS Average Case/Con. (%) Difference (%) P FDR ID Dis. to TSS Average Case/Con. (%) Difference (%) P
UBASH3A 13517 -156 45.6/35.5 10.1 5.00 × 10-6 0.14 146 52 45.6/37.7 7.9 0.145
CTNND1 6160 -431 57.4/70.2 -12.8 2.00 × 10-5 0.20 18016 415 19.7/21.5 -1.8 0.353
TRIM3 17029 -348 6.74/9.28 -2.54 2.40 × 10-5 0.20 19207 -331 12.5/16.2 -3.7 0.035
CTSZ* 23241 -292 13.6/21.0 -7.40 4.40 × 10-5 0.24 1644 -592 17.4/25.6 -8.2 0.001
TRAF5 10097 -319 69.7/58.0 11.7 4.50 × 10-5 0.24 25786 77 1.90/1.79 0.1 0.738
HIPK3 25599 390 51.5/64.9 -13.4 6.50 × 10-5 0.26 5514 314 26.6/35.0 -8.4 0.006
DPCR1 20918 -46 62.5/70.2 -7.70 6.90 × 10-5 0.26 4703 -906 72.4/73.0 -0.6 0.709
HIF3A 2879 153 5.35/2.97 2.38 1.08 × 10-4 0.34 7009 -1445 57.1/63.0 -5.9 0.091
NOTCH4 5969 -51 59.1/68.5 -9.40 1.15 × 10-4 0.34 14700 4 19.3/23.6 -4.3 0.078
CDH5 8829 -243 27.2/36.5 -9.20 1.75 × 10-4 0.44 22286 36 72.5/81.3 -8.8 0.012
CREB3L3 23739 42 9.63/36.7 -27.1 1.78 × 10-3 0.59 13445 -26 5.74/25.8 -20.1 0.004
  1. Genes taken forward to the replication stage are shown in bold.
  2. ID: ID from Illumina HumanMethylation27 BeadChip; Dis. to TSS: Distance to the Transcription Start Site; FDR: False Discover Rate
  3. * For CTSZ, 7 CpG sites were included in the genome-wide methylation platform and the two most significant sites are listed in the table.