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Table 1 Distribution of analyzed variables according to diagnostic group and unadjusted Odds Ratio over the derivation cohort.

From: Ruling out coronary heart disease in primary care patients with chest pain: a clinical prediction score

Variables Validation
cohort
Derivation
cohort
  (n = 774) All
(n = 661)
CHD group
(n= 85)
Non-CHD group
(n= 576)
OR(unadjusted)
(95% CI)
  % % n (%) n (%)  
Gender (Male) 42.0% 47.5% 43 (50.6%) 271 (47.0%) 1.2 (0.7 to 1.8)
Age-gender categories      
   M < 55 yr or F < 65 yr 48.4% 57.8% 6 (7.1%) 376 (65.3%) 1
   M 55 to 64 yr or F 65 to 74 yr 26.0% 14.1% 17 (20.0%) 83 (14.4%) 12.8 (4.9 to 33.5)
   M ≥ 65 yr or F ≥ 75 yr 25.6% 27.1% 62 (72.9%) 117 (20.3%) 33.2 (14.0 to 78.7)
Known CVR      
   None 21.2% 34.5% 2 (2.3%) 226 (39.2%) 1
   1-2 53.2% 50.5% 46 (54.1%) 288 (50.0%) 18.1 (4.3 to 15.8)
   ≥3 25.6% 15.0% 37 (43.5%) 62 (10.8%) 67.4 (15.8 to 287.6)
Previous history of CVD 22.0% 18.2% 62 (72.9%) 58 (10.1%) 24.1 (12.5 to 46.4)
Characteristic of the pain      
   Duration 1 to 60 minutes 42.6% 35.2% 66 (77.6%) 167 (29.0%) 8.5 (4.8 to 15.1)
   Increasing on exertion 19.8% 21.3% 37 (43.5%) 104 (18.1%) 3.5 (2.1 to 5.7)
   Substernal area pain 57.5% 16.3% 43 (50.6%) 65 (11.3%) 8.0 (4.7 to 13.7)
   No tenderness on palpation 57.0% 54.3% 74 (87.1%) 285 (49.5%) 6.9 (3.5 to 13.5)
   Sudden excruciating pain n/a 50.1% 34 (40.0%) 297 (51.6%) 0.63 (0.39 to 1.0)
   Oppressive pain 43.4% 36.5% 56 (65.9%) 185 (32.1%) 4.1 (2.5 to 6.7)
   Irradiation 14.0% 9.1% 8 (9.4%) 52 (9.0%) 1.0 (0.5 to 2.3)
   Not position dependant n/a 75.8% 77 (90.6%) 424 (73.6%) 3.5 (1.6 to 7.4)
   Not increased with breathing 78.2% 76.5% 80 (94.1%) 426 (74.0%) 5.6 (2.2 to 14.4)
Digestive symptoms   29.0% 24 (28.2%) 168 (29.2%) 0.96 (0.58 to 1.6)
Context      
   Known patient 91.3% 91.1% 80 (94.1%) 522 (90.6%) 1.7 (0.64 to 4.3)
   New complaint n/a 48.8% 19/83 (22.9%) 295/561 (52.6%) 0.27 (0.15 to 0.46)
   Emergency n/a 29.1% 19 (22.3%) 173/574 (30.1%) 0.67 (0.39 to 1.1)
   Principle complaint 89.3% 52.8% 42/84 (50.0%) 305/573 (53.2%) 0.88 (0.56 to 1.4)
   CVR status unknown (no lab) n/a 4.8% 2 (2.3%) 30 (5.2%) 0.44 (0.1 to 1. 9)
  1. CHD = coronary heart disease; CVD = cardiovascular disease; CVR = cardiovascular risk; OR = odds ratio
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