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Table 5 Odds ratios for breast cancer according to duration for 'exclusive use' of individual SSRIs

From: A population-based case-control study of Selective Serotonin Reuptake Inhibitors (SSRIs) and breast cancer: The impact of duration of use, cumulative dose and latency

No. of SSRI

prescriptions

Exclusive use a

 

Cases

Controls

Unadjusted OR b

(95% CI)

Adjusted OR c

(95% CI)

 

n

(%)

n

(%)

  

No use d (reference)

1,442

(84.8)

14,415

(84.7)

1.00

1.00

Paroxetine

      

1 to 23

57

(3.8)

482

(3.2)

1.18 (0.89, 1.56)

1.17 (0.88, 1.55)

≥24

11

(0.73)

89

(0.6)

1.24 (0.66, 2.32)

1.20 (0.64, 2.25)

Sertraline

      

1 to 23

22

(1.5)

240

(1.6)

0.92 (0.59, 1.42)

0.92 (0.59, 1.42)

≥24

8

(0.5)

44

(0.3)

1.82 (0.85, 3.87)

1.84 (0.86, 3.93)

Fluoxetine

      

1 to 23

38

(2.6)

483

(3.2)

0.79 (0.56, 1.10)

0.79 (0.56, 1.10)

≥24

1

(0.7)

134

(0.9)

0.82 (0.44, 1.52)

0.81 (0.44, 1.51)

Fluvoxamine

      

1 to 23

18

(1.2)

174

(1.2)

1.03 (0.64, 1.69)

1.02 (0.63, 1.67)

≥24

4

(0.3)

30

(0.2)

1.33 (0.47, 3.79)

1.33 (0.47, 3.77)

Citalopram e

      

1 to 23

9

(0.6)

133

(0.9)

Not estimatable

Not estimatable

≥24

0

(0.0)

9

(0.1)

  
  1. OR = odds ratio; CI = confidence interval
  2. a 'Exclusive use' refers to use of only one type of SSRI during the exposure time window two or more years prior to index date.
  3. b Matched on age in five-year age groups but unadjusted for the influence of other risk factors.
  4. c Adjusted for age at index (years), marital status, income support status, residence status, and use of oral contraceptives and/or use of hormone therapy.
  5. d 'No use' (reference category) refers to women with no SSRI prescriptions dispensed two or more years prior to index date.
  6. e Small sample sizes did not allow a complete evaluation of risk for 'exclusive use' of citalopram.