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Table 2 Rate ratios1 and 95% confidence intervals (CIs) for venous thromboembolism, compared with the control cohort2

From: Risk of venous thromboembolism in people admitted to hospital with selected immune-mediated diseases: record-linkage study

  Dataset (years)
Immune-mediated disease (ICD code3) ORLS1 (1963 to 1998) Rate ratio (95% CI) P-value ORLS2 (1999 to 2008) Rate ratio (95% CI) P-value England (1999 to 2008) Rate ratio (95% CI) P-value
Addison's disease (255.4) 1.49 (0.79 to 2.55) 0.20 2.96 (1.53 to 5.20) < 0.001 2.15 (1.86 to 2.47) < 0.001
Ankylosing spondylitis (720) 1.35 (0.80 to 2.13) 0.26 1.18 (0.56 to 2.17) 0.73 1.93 (1.74 to 2.14) < 0.001
Autoimmune haemolytic anaemia (283) 2.83 (1.62 to 4.60) <0.001 3.64 (2.11 to 5.85) <0.001 3.83 (3.43 to 4.25) < 0.001
Chronic active hepatitis (571.4) 2.24 (1.25 to 3.70) 0.003 3.99 (1.46 to 8.72) 0.001 2.04 (1.65 to 2.50) <0.001
Coeliac disease (579.0) 1.35 (0.89 to 1.97) 0.21 1.36 (0.87 to 2.03) 0.17 1.21 (1.11 to 1.33) <0.001
Dermatomyositis, polymyositis (710.3,710.4) 1.98 (0.99 to 3.55) 0.04 2.90 (1.16 to 5.98) 0.009 3.04 (2.60 to 3.54) <0.001
Diabetes mellitus under 30 (250) 2.13 (1.33 to 3.26) 0.001 3.22 (1.79 to 5.54) <0.001 2.58 (2.22 to 2.98) <0.001
Goodpasture's syndrome (446.2) 2.29 (0.28 to 8.28) 0.50 6.89 (1.87 to 17.7) <0.001 2.78 (1.78 to 4.14) <0.001
Hashimoto's thyroiditis (245) 0.89 (0.38 to 1.75) 0.87 0.91 (0.19 to 2.67) 0.91 1.41 (1.15 to 1.72) 0.001
Idiopathic thrombocytopenia purpura (287.3) 2.04 (0.93 to 3.88) 0.05 1.58 (0.97 to 2.42) 0.05 2.09 (1.90 to 2.29) <0.001
Multiple sclerosis (340) 2.24 (1.83 to 2.72) <0.001 2.52 (2.00 to 3.13) <0.001 2.14 (2.03 to 2.26) <0.001
Myasthenia gravis (358) 2.04 (1.09 to 3.49) 0.02 2.34 (1.24 to 4.01) 0.003 2.26 (2.00 to 2.54) <0.001
Myxoedema (244) 1.47 (1.27 to 1.70) <0.001 1.36 (1.22 to 1.52) <0.001 1.30 (1.27 to 1.33) <0.001
Pemphigus, pemphigoid (694.4,694.5) 2.69 (1.90 to 3.70) <0.001 3.28 (2.07 to 4.94) < 0.001 2.22 (2.00 to 2.45) <0.001
Pernicious anaemia (281) 1.20 (0.99 to 1.44) 0.06 1.44 (0.97 to 2.07) 0.06 1.36 (1.27 to 1.45) <0.001
Polyarteritis nodosa (446) 2.88 (1.70 to 4.55) <0.001 4.36 (0.90 to 12.8) 0.03 3.53 (2.76 to 4.44) <0.001
Primary biliary cirrhosis (571.6) 1.29 (0.52 to 2.67) 0.64 2.76 (1.37 to 4.95) 0.001 1.49 (1.26 to 1.74) <0.001
Psoriasis (696.0,696.1,696.8,696.9) 1.62 (1.32 to 1.98) <0.001 1.65 (1.23 to 2.17) <0.001 1.66 (1.57 to 1.75) <0.001
Rheumatoid arthritis (714) 1.45 (1.31 to 1.60) <0.001 1.57 (1.37 to 1.79) <0.001 1.75 (1.70 to 1.80) <0.001
Scleroderma (710.1) 2.16 (0.99 to 4.10) 0.03 1.53 (0.70 to 2.91) 0.29 1.97 (1.73 to 2.23) <0.001
Sjogren's syndrome (710.2) 2.85 (1.37 to 5.25) 0.001 1.91 (1.02 to 3.28) 0.03 2.02 (1.80 to 2.26) <0.001
Systemic lupus erythematosus (710.0) 3.61 (2.36 to 5.31) <0.001 4.60 (3.19 to 6.43) <0.001 3.71 (3.43 to 4.02) <0.001
Thyrotoxicosis (242) 1.14 (0.95 to 1.36) 0.14 1.56 (1.23 to 1.95) <0.001 1.34 (1.27 to 1.42) <0.001
  1. 1 Adjusted for sex, age in five-year bands, time-period in single calendar years and district of residence in the ORLS datasets; and for sex, age in five-year bands, time-period in single calendar years, region of residence and deprivation score associated with patients' area of residence, in quintiles, in the England dataset. The rate ratios are calculated as the ratio of the observed/expected number in the cohort for each immune-mediated disease (see Appendix) to the observed/expected numbers in the reference cohort as calculated in the analysis undertaken for each of the individual disease (data not shown).
  2. 2 Conditions used in reference cohort, with Office of Population, Censuses and Surveys (OPCS) code edition 3 for operations and ICD9 code for diagnosis) (with equivalent codes used for other coding editions): appendicectomy (OPCS3 441), squint (ICD9 378), otitis externa, otitis media (380 to 382), haemorrhoids (455), deflected septum, nasal polyp (470 to 471), impacted tooth and other disorders of teeth (520 to 521), inguinal hernia (550)), ingrown toenail and other diseases of nail (703), sebaceous cyst (706.2), internal derangement of knee (717), bunion (727.1), dislocations, sprains and strains (830 to 839, 840 to 848), superficial injury and contusion (910 to 919, 920 to 924).
  3. 3 ICD 9 codes for each immune-mediated disease (equivalent codes were used for cases coded in ICD Revisions 7, 8 and 10.)