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Table 4 Dose intensity (DI)

From: A randomized phase III trial of adjuvant chemotherapy with irinotecan, leucovorin and fluorouracil versus leucovorin and fluorouracil for stage II and III colon cancer: A Hellenic Cooperative Oncology Group study

 

Arm A: IRI+LV+5FU N = 427

Arm B: LV+5FU N = 418

P

DI of irinotecan (mg/m2/wk)

   

   Median

50.5

NA*

 

   Range

11 to 68

NA

 

Relative DI of irinotecan

   

   Median

0.95

NA

 

   Range

0.21 to 1.27

NA

 

DI of LV (mg/m 2 /wk)

  

< 0.001

   Median

129

131

 

   Range

32 to 165

21 to 279

 

Relative DI of LV

   

   Median

0.96

0.87

 

   Range

0.24 to 1.24

0.14 to 1.86

 

DI of 5FU (mg/m 2 /wk)

  

< 0.001

   Median

291

322

 

   Range

73 to 380

54 to 411

 

Relative DI of 5FU

   

   Median

0.97

0.86

 

   Range

0.24 to 1.27

0.14 to 1.10

 

*Not applicable

   
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BMC Medicine

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