Table 5 Incidence of Grades 3 and 4 toxicities (treatment as administered)

From: A randomized phase III trial of adjuvant chemotherapy with irinotecan, leucovorin and fluorouracil versus leucovorin and fluorouracil for stage II and III colon cancer: A Hellenic Cooperative Oncology Group study

	Arm A: IRI+LV+5FU (N = 427)		Arm B: LV+5FU (N = 418)
	n (%)		n (%)
	Grade 3	Grade 4	Grade 3	Grade 4
Leukopenia	10 (2)	0	2 (0.5)	0
Neutropenia	39 (9)	6 (1)	7 (2)	4 (1)
Anemia	2 (0.5)	0	0	0
Thrombocytopenia	2 (0.5)	0	0	0
Diarrhea	58 (14)	6 (1)	52 (12)	2 (0.5)
Nausea/vomiting	7 (2)	0	1 (0.2)	0
Alopecia	6 (1)	0	1 (0.2)	0
Neutropenic fever	4 (1)	0	1 (0.2)	0
Constipation	2 (0.5)	0	1 (0.2)	0
Pain	1 (0.2)	0	2 (0.5)	0
Hepatotoxicity	1 (0.2)	0	2 (0.5)	0
Mucositis	0	0	2 (0.5)	0
Fatigue	1 (0.2)	0	0	0
Watery eye	0	0	1 (0.2)	0
Peripheral neuropathy	0	0	1 (0.2)	0
Skin	0	0	1 (0.2)	0

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