A functional tandem-repeats polymorphism in the downstream of TERTis associated with the risk of nasopharyngeal carcinoma in Chinese population

Table 1 The genotype and allele frequencies of MNS16A in patients with nasopharyngeal carcinoma and cancer-free controls

MNS16A^a	Cases, n (%), n = 798^b	Controls, n (%), n = 1019^b	OR (95% CI)^c,d	P ^c
Alleles, bp
302 (reference)	1520 (95. 2)	1903 (93. 4)	1. 00
243	44 (2. 8)	76 (3. 7)	0. 74 (0. 51 to 1. 08)	0. 12
272	31 (1. 9)	59 (2. 9)	0. 65 (0. 42 to 1. 01)	0. 058
333	1 (0. 06)	0	-	-
Genotypes
302/302 (reference)	724 (90. 7)	891 (87. 4)	1. 00
243/302	41 (5. 2)	65 (6. 4)	0. 80 (0. 53 to 1. 20)	0. 29
272/302	30 (3. 8)	56 (5. 5)	0. 64 (0. 41 to 1. 01)	0. 059
243/243	1 (0. 1)	4 (0. 4)	0. 36 (0. 04 to 3. 73)	0. 41
243/272	1 (0. 1)	3 (0. 3)	0. 33 (0. 04 to 2. 94)	0. 32
302/333	1 (0. 1)	0	-	-
Group of genotypes
LL (reference)	725 (90. 9)	891 (87. 4)	1. 00
SL	71 (8. 9)	121 (11. 9)	0. 73 (0. 53 to 0. 99)	0. 037
SS	2 (0. 2)	7 (0. 7)	0. 35 (0. 07 to 1. 69)	0. 17
SL + SS	73 (9. 1)	128 (12. 6)	0. 71 (0. 52 to 0. 96)	0. 025
Group of alleles
L (reference)	1521 (95. 0)	1903 (93. 0)	1. 00
S	75 (5. 0)	135 (7. 0)	0. 86 (0. 78 to 0. 96)	0. 014

^aOwing to genotyping failure, the actual sample size was 798 and 1019 for the cases and controls, respectively.
^b L allele was 302 or 333 bp; S allele was 243 or 272 bp.
^cThe odds ratios (ORs) and P values were adjusted for age, gender, tobacco and alcohol use, smoking level, ethnicity and family history.
^dConfidence interval.

ISSN: 1741-7015