Figure 2

Distribution of plasma glucose levels after midnight in young people and adults during (top panel) closed-loop and (bottom panel) conventional insulin-pump therapy (continuous subcutaneous insulin infusion (CSII)). Vertical dashed lines indicate the threshold of significant hypoglycemia (3.0 mmol/l) and the target glucose range of 3.91 to 8.0 mmol/l. Values at the top denote the percentage of plasma glucose values within the respective glucose ranges (reproduced with permission from Kumareswaran et al. [60]).