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Table 6 Weight management, blood glucose and blood lipids: Saccharide vs Saccharide

From: A systematic review on the effect of sweeteners on glycemic response and clinically relevant outcomes

Comparison Population Timepoint (week) No of participants MD (95% CI)
BMI, kg/m2
Honey vs Sucrose Overweight/Obese 4 55 -0.5 (-3.1,2.1)
Isomaltulose/Sucrose vs Sucrose General 12 50 -0.04 (-0.4,0.3)
Weight, kg
Fructose vs Glucose General 6 24 0.1 (-3.4,3.6)
Fructose vs Glucose General 1 11 -0.4 (-3.1,2.3)
FOS vs Glucose DM2 3 20 0.2 (-5.2,5.6)
FOS vs Sucrose General 4 12 1.0 (-2.4,4.4)
Honey vs Sucrose Overweight/Obese 4 55 -1.5 (-6.9,3.9)
Isomaltulose/Sucrose vs Sucrose General 12 50 -0.06 (-0.9,0.8)
Sucrose vs Glucose General 2 10 0.2 (-0.07,0.4)
Energy Intake, kcal
FOS vs Glucose DM2 3 20 -139 (-399,122)
FOS vs Sucrose General 4 12 -56 (-156,43)
HbA1C, %
FOS vs Sucrose DM2 4 10 0.17 (-0.59,0.93)
Isomaltulose/Sucrose vs Sucrose General 12 50 0.01 (-0.05,0.07)
HOMA Index
Isomaltulose/Sucrose vs Sucrose General 12 50 -0.44 (-0.76,-0.12)
Total Cholesterol, mmol/L
Fructose vs Glucose General 1 11 0.10 (-0.24,0.44)
FOS vs Glucose DM2 3 20 0.20 (-0.27,0.67)
FOS vs Sucrose DM2 4 10 0.15 (-0.24,0.54)
FOS vs Sucrose General 4 12 0.31 (0.03,0.59)
Honey vs Sucrose Overweight/Obese 4 55 -0.11 (-0.26,0.05)
Isomaltulose/Sucrose vs Sucrose General 12 50 -0.10 (-0.17,-0.02)
Tagatose vs Sucrose General 4 12 -0.11 (-0.51,0.29)
LDL Cholesterol, mmol/L
Fructose vs Glucose General 1 11 0 (-0.17,0.17)
FOS vs Sucrose DM2 4 10 0.13 (-0.21,0.47)
Honey vs Sucrose Overweight/Obese 4 55 -0.03 (-0.22,0.16)
Isomaltulose/Sucrose vs Sucrose General 12 50 -0.02 (-0.08,0.04)
Tagatose vs Sucrose General 4 12 0.09 (-0.26,0.44)
HDL Cholesterol, mmol/L
Fructose vs Glucose General 1 11 0 (-0.17,0.17)
FOS vs Sucrose General 4 12 -0.06 (-0.14,0.02)
FOS vs Sucrose DM2 4 10 0.07 (-0.03,0.17)
Honey vs Sucrose Overweight/Obese 4 55 0.01 (-0.12,0.14)
Isomaltulose/Sucrose vs Sucrose General 12 50 -0.02 (-0.05,0.01)
Tagatose vs Sucrose General 4 12 -0.17 (-0.28,0.06)
Triglycerides, mmol/L
FOS vs Glucose DM2 3 20 0.12 (-0.30,0.54)
FOS vs Sucrose General 4 12 0.18 (-0.03,0.39)
FOS vs Sucrose DM2 4 10 -0.18 (-0.38,0.02)
Honey vs Sucrose Overweight/Obese 4 55 -0.10 (-0.22,0.02)
Isomaltulose vs Sucrose General 12 50 -0.27 (-0.44,-0.10)
  1. *Aspartame, acesulfame, cyclamate, saccharin
  2. DM1 Type 1 Diabetes Mellitus, DM2 Type 2 Diabetes Mellitus, BMI Body mass index, HbA1C Glycated hemoglobin, HOMA Homeostatic Model Assessment, MD Mean difference, CI Confidence interval
  3. Statistically significant results are bolded.