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Table 3 Genotype and allele distributions of SNPs in the MUC4 gene in endometriosis patients at different clinical stagesa

From: MUC4gene polymorphisms associate with endometriosis development and endometriosis-related infertility

SNP

Genotype/allele

No. (%) at mild stageb

No. (%) at severe stagec

Pvalue

rs882605

TT

0

(0.0)

7

(8.0)

0.25

 

TG

2

(25.0)

41

(46.6)

 
 

GG

6

(75.0)

40

(45.5)

 
 

TT+TG

2

(25.0)

48

(54.5)

0.11

 

GG

6

(75.0)

40

(45.5)

 
 

T

2

(12.5)

55

(31.3)

0.12

 

G

14

(87.5)

121

(68.8)

 

rs1104760

CC

0

(0.0)

5

(5.8)

0.05

 

CT

0

(0.0)

36

(41.9)

 
 

TT

7

(100.0)

45

(52.3)

 
 

CC+CT

0

(0.0)

41

(47.7)

0.0d

 

TT

7

(100.0)

45

(52.3)

 
 

C

0

(0.0)

46

(26.7)

0.03d

 

T

14

(100.0)

126

(73.3)

 

rs2688513

CC

0

(0.0)

6

(6.9)

0.04d

 

CT

0

(0.0)

34

(39.1)

 
 

TT

8

(100.0)

47

(54.0)

 
 

CC+CT

0

(0.0)

40

(46.0)

0.01d

 

TT

8

(100.0)

47

(54.0)

 
 

C

0

(0.0)

46

(26.4)

0.02d

 

T

16

(100.0)

128

(73.6)

 

rs2246901

GG

0

(0.0)

6

(6.8)

0.03d

 

TG

0

(0.0)

36

(40.9)

 
 

TT

8

(100.0)

46

(52.3)

 
 

GG+TG

0

(0.0)

42

(47.7)

0.01d

 

TT

8

(100.0)

46

(52.3)

 
 

G

0

(0.0)

48

(27.3)

0.02d

 

T

16

(100.0)

128

(72.7)

 

rs2258447

AA

0

(0.0)

7

(7.9)

0.08

 

AG

0

(0.0)

32

(36.0)

 
 

GG

7

(100.0)

50

(56.2)

 
 

AA+AG

0

(0.0)

39

(43.8)

0.02d

 

GG

7

(100.0)

50

(56.2)

 
 

A

0

(0.0)

46

(25.8)

0.03d

 

G

14

(100.0)

132

(74.2)

 

rs2291652

CC

0

(0.0)

7

(8.3)

0.61

 

CT

2

(33.3)

36

(42.9)

 
 

TT

4

(66.7)

41

(48.8)

 
 

CC+CT

2

(33.3)

43

(51.2)

0.40

 

TT

4

(66.7)

41

(48.8)

 
 

C

2

(16.7)

50

(29.8)

0.33

 

T

10

(83.3)

118

(70.2)

 
  1. aSNP, single-nucleotide polymorphism; MUC4, mucin 4 gene. Allelic frequencies were determined by Fisher's exact test using 2 × 2 contingency tables. Genotype frequencies were determined by Fisher's exact test using 2 × 3 contingency tables. bMild stage, patients at clinical stage1 or stage 2; cSevere stage, patients at clinical stage 3 or stage 4; d P < 0.05 was considered statistically significant.