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Table 4 Genotype and allele distributions of the six SNPs in the MUC4 gene in endometriosis patients with different reproductive abilitya

From: MUC4gene polymorphisms associate with endometriosis development and endometriosis-related infertility

SNP

Genotype/allele

No. (%) infertility

No. (%) noninfertility

Pvalue

OR (95% CI)

rs882605

TT

0

(0.0)

8

(8.7)

0.07

-

-

 

TG

5

(26.3)

42

(45.7)

 

0.36

(0.12 to 1.08)

 

GG

14

(73.7)

42

(45.7)

 

1.00

Reference

 

T

5

(13.2)

58

(31.5)

0.03b

0.33

(0.12 to 0.89)

 

G

33

(86.8)

126

(68.5)

 

1.00

Reference

rs1104760

CC

0

(0.0)

6

(6.3)

0.41

-

-

 

CT

4

(25.0)

37

(38.5)

 

0.48

(0.14 to 1.60)

 

TT

12

(75.0)

53

(55.2)

 

1.00

Reference

 

C

4

(12.5)

49

(25.5)

0.12

0.42

(0.14 to 1.25)

 

T

28

(87.5)

143

(74.5)

 

1.00

Reference

rs2688513

CC

0

(0.0)

7

(7.4)

0.32

-

-

 

TC

5

(25.0)

34

(36.2)

 

0.52

(0.17 to 1.56)

 

TT

15

(75.0)

53

(56.4)

 

1.00

Reference

 

C

5

(12.5)

48

(25.5)

0.09

0.42

(0.15 to 1.12)

 

T

35

(87.5)

140

(74.5)

 

1.00

Reference

rs2246901

GG

0

(0.0)

7

(7.4)

0.25

-

-

 

TG

5

(25.0)

37

(38.9)

 

0.46

(0.15 to 1.38)

 

TT

15

(75.0)

51

(53.7)

 

1.00

Reference

 

G

5

(12.5)

51

(26.8)

0.06

0.39

(0.14 to 1.05)

 

T

35

(87.5)

139

(73.2)

 

1.00

Reference

rs2258447

AA

1

(5.0)

7

(7.3)

0.41

0.53

(0.05 to 5.53)

 

AG

4

(20.0)

33

(34.4)

 

0.45

(0.14 to 1.48)

 

GG

15

(75.0)

56

(58.3)

 

1.00

Reference

 

A

6

(15.0)

47

(24.5)

0.22

0.54

(0.22 to 1.38)

 

G

34

(85.0)

145

(75.5)

 

1.00

Reference

rs2291652

CC

0

(0.0)

7

(7.8)

0.29

-

-

 

CT

7

(35.0)

40

(44.4)

 

0.58

(0.21 to 1.60)

 

TT

13

(65.0)

43

(47.8)

 

1.00

Reference

 

C

7

(17.5)

54

(30.0)

0.12

0.49

(0.21 to 1.19)

 

T

33

(82.5)

126

(70.0)

 

1.00

Reference

  1. aSNP, single-nucleotide polymorphism; MUC4, mucin 4 gene; OR, odds ratio; 95% CI, 95% confidence interval. Allelic frequencies were determined by Fisher's exact test using 2 × 2 contingency tables. Genotype frequencies were determined by Fisher's exact test using 2 × 3 contingency tables. b P < 0.05 was considered statistically significant.