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Table 1 Single gene differences (at FDR = 0) by BOEC from AA (n = 21) versus CA (n = 17).*

From: Differential endothelial cell gene expression by African Americans versusCaucasian Americans: a possible contribution to health disparity in vascular disease and cancer

Affymetrix ID

Gene Name

FDR

Fold Change (AA vs CA)

Welch t-test (P)

Gene Description

205048_s_at

"PSPH" ‡

0

4.08

4 × 10-9

Phosphoserine Phosphatase

212777_at

SOS1

0

1.36

1 × 10-7

Son of Sevenless Homolog 1

202203_s_at

AMFR

0

1.72

4 × 10-6

Autocrine Motility Factor Receptor

204379_s_at

FGFR3

0

1.24

2 × 10-5

Fibroblast Growth Factor Receptor 3

219417_s_at

FLJ20014

0

0.91

6 × 10-5

Chromosome 17 Open Reading Frame 59

208416_s_at

SPTB

0

0.91

1.9 × 10-4

Spectrin, Beta, Erythrocytic

206763_at

FKBP6

0

0.90

6 × 10-5

FK506 Binding Partner 6, 36 kDa

202253_s_at

DNM2

0

0.90

2.3 × 10-4

Dynamin 2

214380_at

PRPF31

0

0.90

9 × 10-5

Precursor mRNA-processing Factor 31, S. Cerevisiae, Homolog of

213209_at

TAF6L

0

0.89

8 × 10-7

TAF6-like RNA Polymerase II, p300/6CBP Associated Factor (PCAF), Associated factor, p65

216204_at

ARVCF

0

0.89

4 × 10-6

Armadillo Repeat Gene Deletes in Velocardiofacial Syndrome

213585_s_at

PDCD2

0

0.89

3 × 10-5

Programmed Cell Death 2

201572_x_at

DCTD

0

0.89

2.1 × 10-4

Deoxycytidylate Deaminase

203589_s_at

TFDP2

0

0.89

3.3 × 10-4

Transcription Factor DP-2 (E2F Dimerization Partner 2)

211096_at

PBX2

0

0.88

3 × 10-6

Pre B-cell Leukemia Transcription Factor 2

215844_at

TNPO2

0

0.88

8 × 10-5

Transportin 2

206182_at

ZNF134

0

0.88

2.3 × 10-4

Zinc Finger Protein 134

219125_s_at

LOC55974

0

0.87

2 × 10-5

Stromal Cell Protein

201557_at

VAMP2

0

0.87

6 × 10-5

Vesicle-associated Membrane Protein 2 (Synaptobrevin2)

202700_s_at

KIAA0792

0

0.87

1.3 × 10-4

Transmembrane Protein 63A

209009_at

ESD

0

0.87

2 × 10-4

Esterase D

200076_s_at

MGC2749

0

0.86

3 × 10-5

Hypothetical Protein MGC2749

207415_at

PLA2R1

0

0.86

2 × 10-5

Phospholipase A2 Receptor 1, 180 kDa

222129_at

C2orf17

0

0.86

1.6 × 10-4

Chromosome X Open Reading Frame 17

202646_s_at

D1S155E

0

0.85

1.1 × 10-4

Cold-shock Domain-containing E1, RNA-binding; CSDE1

222199_s_at

BIN3

0

0.85

7 × 10-5

Bridging Integrator 3

219939_s_at

D1S155E

0

0.82

1 × 10-4

Cold-shock Domain-containing E1, RNA-binding; CSDE1

203538_at

CAMLG

0

0.82

7 × 10-4

Calcium-modulating Cyclophilin Ligand

208757_at

HSGP25L2G

0

0.81

1 × 10-6

GP25L2 Protein

218354_at

LOC51693

0

0.81

3.5 × 10-4

Hematopoietic Stem/progenitor Cells 176

204340_at

CXorf12

0

0.77

2 × 10-4

Chromosome X Open Reading Frame 12

219599_at

EIF4B

0

0.76

4 × 10-5

Eukaryotic Translation Initiation Factor 4B

  1. *This table shows only those genes that meet the very high stringency level of FDR = 0 by SAM (Significance Analysis of Microarray). Genes are ranked by fold change (AA versus CA) so that those with the greatest up-regulation are at top of the list, but those with the greatest down-regulation are at the bottom. All transcripts exhibiting higher expression in AA versus CA subjects, using the less stringent significance threshold of FDR <.05, are shown in Additional File 3 (n = 21 probe sets, representing 20 genes). Likewise, all transcripts exhibiting lower expression in AA versus CA subjects at FDR <.05 are shown in Additional File 4 (n = 200 probe sets, representing 184 genes).
  2. ‡This gene designation from Affymetrix is incorrect - see Figure 1
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BMC Medicine

ISSN: 1741-7015

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