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Hypoperfusion of brain parenchyma is associated with the severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis: a cross-sectional preliminary report

  • Paolo Zamboni1Email author,
  • Erica Menegatti1,
  • Bianca Weinstock-Guttman2,
  • Michael G Dwyer3,
  • Claudiu V Schirda3,
  • Anna M Malagoni1,
  • David Hojnacki2,
  • Cheryl Kennedy3,
  • Ellen Carl3,
  • Niels Bergsland3,
  • Christopher Magnano3,
  • Ilaria Bartolomei1,
  • Fabrizio Salvi1 and
  • Robert Zivadinov2, 3
BMC Medicine20119:22

Received: 12 January 2011

Accepted: 7 March 2011

Published: 7 March 2011

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
12 Jan 2011 Submitted Original manuscript
18 Jan 2011 Author responded Author comments - Paolo Zamboni
Resubmission - Version 2
18 Jan 2011 Submitted Manuscript version 2
7 Mar 2011 Editorially accepted
7 Mar 2011 Article published 10.1186/1741-7015-9-22

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

Vascular Diseases Center, University of Ferrara-Bellaria Neurosciences, Ferrara and Bologna
The Jacobs Neurological Institute, University at Buffalo
Buffalo Neuroimaging Analysis Center, University at Buffalo