'Gut health': a new objective in medicine?

Table 2 Diseases thought to be associated with GI barrier and GI microbiota^a

Location	Diseases for which the GI barrier plays a central role in pathogenesis	Diseases associated with an altered composition or function of the GI microbiota
Intestinal	Infectious diarrhoea [26, 36] Inflammatory bowel disease [130–132] Coeliac disease [131] Irritable bowel syndrome [133]	Inflammatory bowel disease [138, 139] Coeliac disease [140] Irritable bowel syndrome [141, 142]
Extraintestinal	Allergic diseases [20, 134, 135] Autoimmune diseases and arthritis [17] Obesity, fatty liver disease and nonalcoholic steatohepatitis (NASH) [35, 136, 137] Systemic inflammatory response syndrome (SIRS) and sepsis in ICU patients [36, 37] Malnutrition [40]	Allergic diseases [143, 144] Arthritis [145] Obesity [125]

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