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Table 2 Diseases thought to be associated with GI barrier and GI microbiotaa

From: 'Gut health': a new objective in medicine?

Location Diseases for which the GI barrier plays a central role in pathogenesis Diseases associated with an altered composition or function of the GI microbiota
Intestinal Infectious diarrhoea [26, 36]
Inflammatory bowel disease [130132]
Coeliac disease [131]
Irritable bowel syndrome [133]
Inflammatory bowel disease [138, 139]
Coeliac disease [140]
Irritable bowel syndrome [141, 142]
Extraintestinal Allergic diseases [20, 134, 135]
Autoimmune diseases and arthritis [17]
Obesity, fatty liver disease and nonalcoholic steatohepatitis (NASH) [35, 136, 137]
Systemic inflammatory response syndrome (SIRS) and sepsis in ICU patients [36, 37]
Malnutrition [40]
Allergic diseases [143, 144]
Arthritis [145]
Obesity [125]
  1. aGI, gastrointestinal; ICU, intensive care unit.