Relationship between dysfunctional adipose tissue in obesity, inflammation, hypoxia, and obesity-related disorders. Adipose tissue mass increases during obesity, which leads to a state in which the adipose tissue becomes hypoxic. There is a dysregulation in the synthesis of adipokines in favor of the proinflammatory ones. This might lead to obesity-related disorders and results in inflammation within adipose tissue. Hypoxia may underlie this inflammatory response by supporting the production of proinflammatory adipokines.