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Figure 2 | BMC Medicine

Figure 2

From: Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer

Figure 2

Loss of lamin A/C expression in ovarian cancers. Ovarian normal and tumor tissues were analyzed by immunostaining for lamin A/C. (A) A representative example shows that lamin A/C is strongly stained around the nucleus of normal ovarian surface epithelial cells. The nuclei are generally smooth and oval-shaped in all normal ovarian surface epithelial cells. (B) Two examples show loss of lamin A/C expression in ovarian carcinomas. Some stromal cells show strong lamin A/C staining around the nucleus, serving as an internal positive control. The nuclear morphology of tumor cells is heterogeneous, and some cells with large and deformed nuclei are present. (C) A representative example of ovarian carcinomas showing heterogeneous expression of lamin A/C among the tumor cells. (D) An example of ovarian carcinomas contiguous with the benign ovarian surface epithelium. Lamin A/C is lost in the transformed cells. In an adjacent section, the loss of lamin A/C correlates with the distribution of emerin to the cytoplasm of tumor cells.

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