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Table 1 Baseline Demographic and Clinical Characteristics Comparing Clopidogrel Low Responder and Responder

From: Tailored antiplatelet therapy can overcome clopidogrel and aspirin resistance - The BOchum CLopidogrel and Aspirin Plan (BOCLA-Plan) to improve antiplatelet therapy

Variable Clopidogrel Low-Responder Clopidogrel Responder OR (95% CI) p-Value
No. (%) 155 (30.8) 349 (69.2)   
Female gender (%) 54 (34.8) 101 (28.9) 1.31 (0.88-1.97) n.s. (0.21)
Age (years) 64.5 (11.5) 64.4 (11.7)   n.s. (0.93)
BMI (kg/m2) 28.06 (5.00) 27.81 (4.20)   n.s. (0.56)
EF (%) 52.82 (12.50) 54.23 (10.50)   n.s. (0.19)
Acute coronary syndrome 122 (78.7) 214 (61.3) 2.33 (1.50-3.63) <0.001
Arterial hypertension 124 (80.0) 282 (80.8) 0.95 (0.59-1.53) n.s. (0.90)
Diabetes mellitus 74 (47.7) 124 (35.5) 1.66 (1.13-2.43) 0.01
Lipid disorder 95 (61.3) 211 (60.5) 1.04 (0.70-1.53) n.s. (0.92)
Cigarette smoking 68 (43.9) 157 (45.0) 0.96 (0.65-1.40) n.s. (0.85)
Familial CAD disposition 33 (21.3) 63 (18.1) 1.23 (0.77-1.97) n.s. (0.39)
ASA 100 mg 153 (98.7) 349 (100) 0.09 (0.01-1.84) n.s. (0.09)
Beta-Blockers 138 (89.0) 302 (86.5) 1.26 (0.70-2.28) n.s. (0.47)
Nitrates 24 (15.5) 72 (20.6) 0.70 (0.42-1.17) n.s. (0.22)
Calcium-channel blockers 49 (31.6) 101 (28.9) 1.14 (0.75-1.71) n.s. (0.60)
ACE Inhibitors 133 (85.8) 301 (86.2) 0.96 (0.56-1.66) n.s. (0.89)
Diuretics 73 (47.1) 138 (39.5) 1.36 (0.93-1.99) n.s. (0.12)
Statins 125 (80.6) 269 (77.1) 1.24 (0.77-1.98) n.s. (0.41)
Proton pump inhibitors 62 (40.0) 151 (43.3) 0.87 (0.59-1.29) n.s. (0.56)
Number of drugs 7.69 (2.30) 7.36 (2.30)   n.s. (0.14)
WBC (×109/l) 9.22 (4.17) 8.71 (6.10)   n.s. (0.34)
Hemoglobin (g/dl) 14.12 (1.60) 14.28 (1.90)   n.s. (0.36)
Platelet count (×109/l) 230.34 (69.62) 212.00 (87.97)   0.02
Troponin positive (%) 35 (22.6) 37 (10.6) 2.46 (1.48-4.09) <0.001
CK max (U/l) 428.85 (1246.60) 391.61 (783.70)   n.s. (0.68)
Total cholesterol (mg/dl) 203.70 (57.30) 204.37 (50.10)   n.s. (0.89)
CRP (mg/l) 11.47 (20.70) 7.34 (15.40)   0.01
HbA1C (%) 6.71 (1.60) 6.42 (1.30)   0.03
D-dimer (mg/l) 0.57 (0.50) 0.57 (0.40)   n.s. (1.00)
Serum creatinine (mg/dl) 1.06 (0.60) 1.04 (0.30)   n.s. (0.62)
GFR (MDRD) (ml/min) 76.34 (24.20) 75.87 (20.90)   n.s. (0.82)
PREDICT-score 3.38 (2.0) 2.48 (1.90)   <0.001
ASA low-response 44 (28.4) 31 (8.9) 4.07 (2.45-6.76) <0.001
  1. Data presented are mean ± SD and count (no.) or percentage (%). Calculation of p-values was done by unpaired t-test or chi-square test, comparing low-responder versus responder. OR = odds ratio; CI = confidence interval; n.s. = not significant.
  2. BMI = body mass index, EF = ejection fraction, CAD = coronary artery disease, ASA = acetylsalicylic acid (aspirin), ACE = angiotensin-converting enzyme, WBC = white blood cells, CK = creatine kinase, CRP = C-reactive protein, HbA1C = hemoglobin A1c, GFR = glomerular filtration rate.
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