|
Variable
|
Clopidogrel Low-Responder
|
Clopidogrel Responder
|
OR (95% CI)
|
p-Value
|
|---|
|
No. (%)
|
155 (30.8)
|
349 (69.2)
| | |
|
Female gender (%)
|
54 (34.8)
|
101 (28.9)
|
1.31 (0.88-1.97)
|
n.s. (0.21)
|
|
Age (years)
|
64.5 (11.5)
|
64.4 (11.7)
| |
n.s. (0.93)
|
|
BMI (kg/m2)
|
28.06 (5.00)
|
27.81 (4.20)
| |
n.s. (0.56)
|
|
EF (%)
|
52.82 (12.50)
|
54.23 (10.50)
| |
n.s. (0.19)
|
|
Acute coronary syndrome
|
122 (78.7)
|
214 (61.3)
|
2.33 (1.50-3.63)
|
<0.001
|
|
Arterial hypertension
|
124 (80.0)
|
282 (80.8)
|
0.95 (0.59-1.53)
|
n.s. (0.90)
|
|
Diabetes mellitus
|
74 (47.7)
|
124 (35.5)
|
1.66 (1.13-2.43)
|
0.01
|
|
Lipid disorder
|
95 (61.3)
|
211 (60.5)
|
1.04 (0.70-1.53)
|
n.s. (0.92)
|
|
Cigarette smoking
|
68 (43.9)
|
157 (45.0)
|
0.96 (0.65-1.40)
|
n.s. (0.85)
|
|
Familial CAD disposition
|
33 (21.3)
|
63 (18.1)
|
1.23 (0.77-1.97)
|
n.s. (0.39)
|
|
ASA 100 mg
|
153 (98.7)
|
349 (100)
|
0.09 (0.01-1.84)
|
n.s. (0.09)
|
|
Beta-Blockers
|
138 (89.0)
|
302 (86.5)
|
1.26 (0.70-2.28)
|
n.s. (0.47)
|
|
Nitrates
|
24 (15.5)
|
72 (20.6)
|
0.70 (0.42-1.17)
|
n.s. (0.22)
|
|
Calcium-channel blockers
|
49 (31.6)
|
101 (28.9)
|
1.14 (0.75-1.71)
|
n.s. (0.60)
|
|
ACE Inhibitors
|
133 (85.8)
|
301 (86.2)
|
0.96 (0.56-1.66)
|
n.s. (0.89)
|
|
Diuretics
|
73 (47.1)
|
138 (39.5)
|
1.36 (0.93-1.99)
|
n.s. (0.12)
|
|
Statins
|
125 (80.6)
|
269 (77.1)
|
1.24 (0.77-1.98)
|
n.s. (0.41)
|
|
Proton pump inhibitors
|
62 (40.0)
|
151 (43.3)
|
0.87 (0.59-1.29)
|
n.s. (0.56)
|
|
Number of drugs
|
7.69 (2.30)
|
7.36 (2.30)
| |
n.s. (0.14)
|
|
WBC (×109/l)
|
9.22 (4.17)
|
8.71 (6.10)
| |
n.s. (0.34)
|
|
Hemoglobin (g/dl)
|
14.12 (1.60)
|
14.28 (1.90)
| |
n.s. (0.36)
|
|
Platelet count (×109/l)
|
230.34 (69.62)
|
212.00 (87.97)
| |
0.02
|
|
Troponin positive (%)
|
35 (22.6)
|
37 (10.6)
|
2.46 (1.48-4.09)
|
<0.001
|
|
CK max (U/l)
|
428.85 (1246.60)
|
391.61 (783.70)
| |
n.s. (0.68)
|
|
Total cholesterol (mg/dl)
|
203.70 (57.30)
|
204.37 (50.10)
| |
n.s. (0.89)
|
|
CRP (mg/l)
|
11.47 (20.70)
|
7.34 (15.40)
| |
0.01
|
|
HbA1C (%)
|
6.71 (1.60)
|
6.42 (1.30)
| |
0.03
|
|
D-dimer (mg/l)
|
0.57 (0.50)
|
0.57 (0.40)
| |
n.s. (1.00)
|
|
Serum creatinine (mg/dl)
|
1.06 (0.60)
|
1.04 (0.30)
| |
n.s. (0.62)
|
|
GFR (MDRD) (ml/min)
|
76.34 (24.20)
|
75.87 (20.90)
| |
n.s. (0.82)
|
|
PREDICT-score
|
3.38 (2.0)
|
2.48 (1.90)
| |
<0.001
|
|
ASA low-response
|
44 (28.4)
|
31 (8.9)
|
4.07 (2.45-6.76)
|
<0.001
|
- Data presented are mean ± SD and count (no.) or percentage (%). Calculation of p-values was done by unpaired t-test or chi-square test, comparing low-responder versus responder. OR = odds ratio; CI = confidence interval; n.s. = not significant.
- BMI = body mass index, EF = ejection fraction, CAD = coronary artery disease, ASA = acetylsalicylic acid (aspirin), ACE = angiotensin-converting enzyme, WBC = white blood cells, CK = creatine kinase, CRP = C-reactive protein, HbA1C = hemoglobin A1c, GFR = glomerular filtration rate.
