Variable | Clopidogrel Low-Responder | Clopidogrel Responder | OR (95% CI) | p-Value |
---|---|---|---|---|
No. (%) | 155 (30.8) | 349 (69.2) | ||
Female gender (%) | 54 (34.8) | 101 (28.9) | 1.31 (0.88-1.97) | n.s. (0.21) |
Age (years) | 64.5 (11.5) | 64.4 (11.7) | n.s. (0.93) | |
BMI (kg/m2) | 28.06 (5.00) | 27.81 (4.20) | n.s. (0.56) | |
EF (%) | 52.82 (12.50) | 54.23 (10.50) | n.s. (0.19) | |
Acute coronary syndrome | 122 (78.7) | 214 (61.3) | 2.33 (1.50-3.63) | <0.001 |
Arterial hypertension | 124 (80.0) | 282 (80.8) | 0.95 (0.59-1.53) | n.s. (0.90) |
Diabetes mellitus | 74 (47.7) | 124 (35.5) | 1.66 (1.13-2.43) | 0.01 |
Lipid disorder | 95 (61.3) | 211 (60.5) | 1.04 (0.70-1.53) | n.s. (0.92) |
Cigarette smoking | 68 (43.9) | 157 (45.0) | 0.96 (0.65-1.40) | n.s. (0.85) |
Familial CAD disposition | 33 (21.3) | 63 (18.1) | 1.23 (0.77-1.97) | n.s. (0.39) |
ASA 100 mg | 153 (98.7) | 349 (100) | 0.09 (0.01-1.84) | n.s. (0.09) |
Beta-Blockers | 138 (89.0) | 302 (86.5) | 1.26 (0.70-2.28) | n.s. (0.47) |
Nitrates | 24 (15.5) | 72 (20.6) | 0.70 (0.42-1.17) | n.s. (0.22) |
Calcium-channel blockers | 49 (31.6) | 101 (28.9) | 1.14 (0.75-1.71) | n.s. (0.60) |
ACE Inhibitors | 133 (85.8) | 301 (86.2) | 0.96 (0.56-1.66) | n.s. (0.89) |
Diuretics | 73 (47.1) | 138 (39.5) | 1.36 (0.93-1.99) | n.s. (0.12) |
Statins | 125 (80.6) | 269 (77.1) | 1.24 (0.77-1.98) | n.s. (0.41) |
Proton pump inhibitors | 62 (40.0) | 151 (43.3) | 0.87 (0.59-1.29) | n.s. (0.56) |
Number of drugs | 7.69 (2.30) | 7.36 (2.30) | n.s. (0.14) | |
WBC (×109/l) | 9.22 (4.17) | 8.71 (6.10) | n.s. (0.34) | |
Hemoglobin (g/dl) | 14.12 (1.60) | 14.28 (1.90) | n.s. (0.36) | |
Platelet count (×109/l) | 230.34 (69.62) | 212.00 (87.97) | 0.02 | |
Troponin positive (%) | 35 (22.6) | 37 (10.6) | 2.46 (1.48-4.09) | <0.001 |
CK max (U/l) | 428.85 (1246.60) | 391.61 (783.70) | n.s. (0.68) | |
Total cholesterol (mg/dl) | 203.70 (57.30) | 204.37 (50.10) | n.s. (0.89) | |
CRP (mg/l) | 11.47 (20.70) | 7.34 (15.40) | 0.01 | |
HbA1C (%) | 6.71 (1.60) | 6.42 (1.30) | 0.03 | |
D-dimer (mg/l) | 0.57 (0.50) | 0.57 (0.40) | n.s. (1.00) | |
Serum creatinine (mg/dl) | 1.06 (0.60) | 1.04 (0.30) | n.s. (0.62) | |
GFR (MDRD) (ml/min) | 76.34 (24.20) | 75.87 (20.90) | n.s. (0.82) | |
PREDICT-score | 3.38 (2.0) | 2.48 (1.90) | <0.001 | |
ASA low-response | 44 (28.4) | 31 (8.9) | 4.07 (2.45-6.76) | <0.001 |