Skip to main content

Table 1 Baseline Demographic and Clinical Characteristics Comparing Clopidogrel Low Responder and Responder

From: Tailored antiplatelet therapy can overcome clopidogrel and aspirin resistance - The BOchum CLopidogrel and Aspirin Plan (BOCLA-Plan) to improve antiplatelet therapy

Variable

Clopidogrel Low-Responder

Clopidogrel Responder

OR (95% CI)

p-Value

No. (%)

155 (30.8)

349 (69.2)

  

Female gender (%)

54 (34.8)

101 (28.9)

1.31 (0.88-1.97)

n.s. (0.21)

Age (years)

64.5 (11.5)

64.4 (11.7)

 

n.s. (0.93)

BMI (kg/m2)

28.06 (5.00)

27.81 (4.20)

 

n.s. (0.56)

EF (%)

52.82 (12.50)

54.23 (10.50)

 

n.s. (0.19)

Acute coronary syndrome

122 (78.7)

214 (61.3)

2.33 (1.50-3.63)

<0.001

Arterial hypertension

124 (80.0)

282 (80.8)

0.95 (0.59-1.53)

n.s. (0.90)

Diabetes mellitus

74 (47.7)

124 (35.5)

1.66 (1.13-2.43)

0.01

Lipid disorder

95 (61.3)

211 (60.5)

1.04 (0.70-1.53)

n.s. (0.92)

Cigarette smoking

68 (43.9)

157 (45.0)

0.96 (0.65-1.40)

n.s. (0.85)

Familial CAD disposition

33 (21.3)

63 (18.1)

1.23 (0.77-1.97)

n.s. (0.39)

ASA 100 mg

153 (98.7)

349 (100)

0.09 (0.01-1.84)

n.s. (0.09)

Beta-Blockers

138 (89.0)

302 (86.5)

1.26 (0.70-2.28)

n.s. (0.47)

Nitrates

24 (15.5)

72 (20.6)

0.70 (0.42-1.17)

n.s. (0.22)

Calcium-channel blockers

49 (31.6)

101 (28.9)

1.14 (0.75-1.71)

n.s. (0.60)

ACE Inhibitors

133 (85.8)

301 (86.2)

0.96 (0.56-1.66)

n.s. (0.89)

Diuretics

73 (47.1)

138 (39.5)

1.36 (0.93-1.99)

n.s. (0.12)

Statins

125 (80.6)

269 (77.1)

1.24 (0.77-1.98)

n.s. (0.41)

Proton pump inhibitors

62 (40.0)

151 (43.3)

0.87 (0.59-1.29)

n.s. (0.56)

Number of drugs

7.69 (2.30)

7.36 (2.30)

 

n.s. (0.14)

WBC (×109/l)

9.22 (4.17)

8.71 (6.10)

 

n.s. (0.34)

Hemoglobin (g/dl)

14.12 (1.60)

14.28 (1.90)

 

n.s. (0.36)

Platelet count (×109/l)

230.34 (69.62)

212.00 (87.97)

 

0.02

Troponin positive (%)

35 (22.6)

37 (10.6)

2.46 (1.48-4.09)

<0.001

CK max (U/l)

428.85 (1246.60)

391.61 (783.70)

 

n.s. (0.68)

Total cholesterol (mg/dl)

203.70 (57.30)

204.37 (50.10)

 

n.s. (0.89)

CRP (mg/l)

11.47 (20.70)

7.34 (15.40)

 

0.01

HbA1C (%)

6.71 (1.60)

6.42 (1.30)

 

0.03

D-dimer (mg/l)

0.57 (0.50)

0.57 (0.40)

 

n.s. (1.00)

Serum creatinine (mg/dl)

1.06 (0.60)

1.04 (0.30)

 

n.s. (0.62)

GFR (MDRD) (ml/min)

76.34 (24.20)

75.87 (20.90)

 

n.s. (0.82)

PREDICT-score

3.38 (2.0)

2.48 (1.90)

 

<0.001

ASA low-response

44 (28.4)

31 (8.9)

4.07 (2.45-6.76)

<0.001

  1. Data presented are mean ± SD and count (no.) or percentage (%). Calculation of p-values was done by unpaired t-test or chi-square test, comparing low-responder versus responder. OR = odds ratio; CI = confidence interval; n.s. = not significant.
  2. BMI = body mass index, EF = ejection fraction, CAD = coronary artery disease, ASA = acetylsalicylic acid (aspirin), ACE = angiotensin-converting enzyme, WBC = white blood cells, CK = creatine kinase, CRP = C-reactive protein, HbA1C = hemoglobin A1c, GFR = glomerular filtration rate.