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Table 1 Type of prescription according to GI risk

From: Prescription patterns and appropriateness of NSAID therapy according to gastrointestinal risk and cardiovascular history in patients with diagnoses of osteoarthritis

Type of drug Low GI risk N (%) Moderate GI risk N (%) High GI risk N (%) P-value**
  N = 1283 N = 5511 N = 10311  
SYSADOA 55 (4.3) 120 (2.2) 80 (0.8) <0.0001
Paracetamol 130 (10.1) 535 (9.7) 841 (8.2) 0.001
Opioids 12 (0.9) 55 (1.0) 59 (0.6) 0.008
Combinations of any of the 3* 80 (6.2) 424 (7.7) 1103 (10.3) <0.0001
NsNSAIDs 615 (47.9) 2,567 (46.6) 4,734 (45.9) 0.337
nsNSAID+ GP*** 344/615 (55.9) 2,093/2,567 (81.5) 4,367/4,734 (92.2) <0.0001
Cox-2 NSAID 294 (22.9) 1,636 (29.7) 3,669 (35.6) <0.0001
Cox-2 + GP*** 96/294 (32.7) 880/1,636 (53.8) 2.800/3,669 (76.3) <0.0001
  1. CV HX = cardiovascular history; GP = gastroprotectant (>91% proton pump inhibitors).
  2. * Sysadoa, paracetamol, opioids; ** P-values denotes differences among groups overall; *** nsNSAIDS + GP data express the number of patients and % of patients with nsNSAIDs prescription that also take a gastroprotective agent. Also, COX-2 + GP data express the number of patients and % of patients with COX-2 selective inhibitors prescriptions that also take a gastroprotective agent.