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Table 2 Type of prescription based on GI risk and CV history

From: Prescription patterns and appropriateness of NSAID therapy according to gastrointestinal risk and cardiovascular history in patients with diagnoses of osteoarthritis

Prescription Low GI risk Mod. GI risk High GI risk P** value
  No CV Hx* CV Hx No CV Hx CV Hx No CV Hx CV Hx  
  N (%) N (%) N (%) N (%) N (%) N (%)  
  N = 1,144 N = 62 N = 4,373 N = 871 N = 5,697 N = 4,323  
SYSADOA 52 (4.6) 0 (0.0) 92 (2.1) 22 (2.5) 44 (0.8) 33 (0.8) <0.0001
Paracetamol 108 (9.4) 13 (21.0) 391 (8.9) 121 (13.9) 331 (5.8) 480 (11.1) <0.0001
Opioids 11 (1.0) 1 (1.6) 40 (0.9) 11 (1.3) 28 (0.5) 28 (0.7) 0.03
Combinations of any of the 3* 72 (6.2) 5 (8.0) 306 (7.0) 97 (11.1) 498 (8.7) 586 (13.5) <0.0001
nsNSAIDs 554 (48.4) 27 (43.5) 2,091 (47.8) 353 (40.5) 2,807 (49.3) 1,789 (41.4) <0.0001
nsNSAID+ GP*** 307/554 (55.4) 18/27 (66.7) 1,687/2,091 (80.7) 302/353 (85.6) 2,552/2,807 (90.9) 1,691/1,789 (94.5) <0.0001
Cox-2 NSAID 267 (23.3) 13 (21.0) 1,335 (30.5) 227 (26.1) 2,154 (37.8) 1,428 (33.0) <0.0001
Cox-2 + GP*** 89/267 (33.3) 4/13 (30.8) 694/1,335 (52.0) 149/227 (65.6) 1,554/2,154 (72.1) 1,177/1,428 (82.4) <0.0001
  1. CV HX = cardiovascular history; GP = gastroprotectant (>91% PPI).
  2. * Sysadoa, paracetamol, opioids; ** P-values denotes differences among groups overall; *** nsNSAIDS + GP data express the number of patients and % of patients with nsNSAIDs prescription that also take a gastroprotective agent. Also, COX-2 + GP data express the number of patients and % of patients with COX-2 selective inhibitors prescriptions that also take a gastroprotective agent.