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Table 2 Blood lipid profiles and cholesterol metabolic gene expressions in study subjects

From: Blood lipid profiles and peripheral blood mononuclear cell cholesterol metabolism gene expression in patients with and without methotrexate treatment

  Normal range Non-MTX users (n = 32) MTX users (n = 67) Pvaluea
TC, mg/dl ≤200 mg/dl 167.5 (162.8 to 192.4) 172.0 (169.3 to 185.5) 0.367
TG, mg/dl ≤150 mg/dl 81.0 (75.7 to 105.1) 71.0 (73.2 to 90.7) 0.344
TC/HDL-C <4 1.34 (1.25 to 1.71) 1.38 (1.30 to 1.59) 0.884
HDL-C, mg/dl ≥60 mg/dl 66.0 (59.4 to 71.8) 69.0 (65.0 to 74.0) 0.410
LDL-C, mg/dl ≤100 mg/dl 85.7 (79.6 to 102.6) 89.0 (85.8 to 99.9) 0.673
LDL-C/HDL-C   2.72 (2.51 to 3.07) 2.60 (2.53 to 2.88) 0.736
ABCA/18S   0.09 (0.03 to 0.77) 0.15 (0.43 to 2.60) 0.021
HY27/18S   0.07 (-0.05 to 1.41) 0.19 (0.32 to 5.40) 0.037
  1. Results are expressed as median (95% CI) (n = 99). Normal ranges of plasma lipid profiles: TC (total cholesterol) ≤200 mg/dl; TG (triglyceride) ≤150 mg/dl; HDL-C (high-density lipoprotein-cholesterol) ≥60 mg/dl; LDL-C (low-density lipoprotein-cholesterol) ≤100 mg/dl.
  2. aData were analyzed by Mann-Whitney U test. Bold text in tables represent significantly different (p < 0.05)
  3. ABCA1 = ATP-binding cassette transporter A1; HY27 = 27-hydroxylase; MTX = methotrexate.