| PneumoADIP | PAHO TriVac | SUPREMES |
---|---|---|---|
Types of study | CEA and CUA | CEA and CUA | CEA and CUA |
Population | Number of live birth of 10 cohorts (secular trend analysis) | Number of births 5 years prior to start of intervention and number of live birth per year | Cross-sectional analysis of entire population |
Perspective | Society | Society and government | Healthcare payera |
Vaccination | Pneumococcal | Pneumococcal, Rotavirus, Hib | Pneumococcalb |
Outcomes | Cost per DALY averted, cost per life year saved | Cost per DALY averted, cost per life saved, cost per life year gained, cost per case averted, cost per hospitalization averted | Cost per QALY gained, cost per life year gained |
Time horizon | 5 years | 5 years | Cross sectional |
Diseases captured | Pneumococcal pneumonia, pneumococcal meningitis, invasive NPNM, otitis media | Pneumococcal pneumonia, pneumococcal meningitis, invasive NPNM | Pneumococcal pneumonia, pneumococcal meningitis, pneumococcal bacteremia, otitis mediac |
Herd immunity | Included only in vaccine-targeted cohorts; no switch 'off' and 'on' | Included only in vaccine-targeted cohorts; can be switched 'off' and 'on' | Included for vaccine targeted and non-targeted population; can be switched 'off' and 'on' |
Serotype replacement | Does not allow an explicit consideration of serotype replacement, (allows for serotype adjustment) | Allows for an explicit direct adjustment for serotype replacement over time | No direct adjustment for serotype replacement over time (the individual component of replacement is included in the direct vaccine effectiveness estimate) |
Sequelae | Pneumococcal pneumonia, pneumococcal meningitis, invasive NPNM | Pneumococcal pneumonia, pneumococcal meningitis, invasive NPNM, pneumococcal OM | Pneumococcal meningitis, pneumococcal OM (can be switch 'off' and 'on') |
Discounting | 3% | 3% | No need for discounting |
Sensitivity analysis | NR | One-way sensitivity analysisd | One-way sensitivity analysise |